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Associations of Angiotensin Converting Enzyme-1 and Angiotensin II Blood Levels and Cognitive Function
Plain-language guide to PMID 29660936 (2018): pilot randomized controlled trial study of Angiotensin II in 56 participants.
Key Facts
- PMID
- 29660936
- Journal
- Journal of Alzheimer's disease : JAD
- Year
- 2018
- Study type
- Randomized Controlled Trial
- Authors
- Yasar S et al. (4 authors)
- DOI
- 10.3233/JAD-170944
What This Study Did, in Plain Language
What Was Tested
This randomized controlled trial paper looks at Angiotensin II.
Their pilot study was aimed to examine associations between blood ACE-1 and ANG II levels and cognitive function in non-demented participants at baseline and over a 1-year period.
Linear regression analysis, adjusting for confounders, was used to determine associations between baseline ACE-1 and ANGII, and baseline and 1-year follow-up measures of psychomotor and processing speed, executive function, verbal learning memory and working memory, and whether these associations were mediated by blood pressure.
Why It Was Studied
Few studies evaluated associations between blood ACE-1 and none between ANGII levels, and cognition.
Who Took Part
The abstract describes 56 participants taking part.
PubMed indexes the participants as older adults, both men and women.
56 participants were included from the Brain Health Substudy of the Baltimore Experience Corps Study.
How the Study Was Run
The design is described as randomized and pilot.
Random assignment meant chance, not the researchers, decided who got Angiotensin II and who got the comparison, which limits bias.
It is described as a pilot, a small early test of whether a larger Angiotensin II study would be practical.
What Was Measured
Few studies evaluated associations between blood ACE-1 and none between ANGII levels, and cognition.
The subject headings attached to it are Angiotensin II, Biomarkers, Cognition, Peptidyl-Dipeptidase A and Pilot Projects.
Author keywords: angiotensin converting enzyme-1 and cohort study.
What This Means in Plain Language
The paper is a randomized and pilot study of Angiotensin II in 56 participants.
The abstract goes on to report its results in about 4 sentences; this page does not restate them, so read the paper for the findings and their limits.
The publication is from 2018 (Journal of Alzheimer's disease : JAD), a journal based in United States.
More context: the Angiotensin II compound page, all human trials.
Our Notes on the Compound
Angiotensin II: An 8-amino-acid hormone that narrows blood vessels; synthetic angiotensin II (Giapreza) is used for low blood pressure in shock.
Related Pages
Source: PubMed record. This explanation is written by PeptideWhiz from the public record. For research and education only. Not medical advice; no dosing information is given.