Hematuria as an adverse outcome following provocative growth hormone stimulation testing in children.

Plain-language guide to PMID 29688887 (2018): observational study of Exogenous HGH, sermorelin & older GHRPs (why they're passed over).

Key Facts

PMID: 29688887
Journal: Journal of pediatric endocrinology & metabolism : JPEM
Year: 2018
Study type: Observational Study
Authors: Thirunagari R et al. (4 authors)
DOI: 10.1515/jpem-2017-0458

What This Study Did, in Plain Language

What Was Tested

Researchers studied Exogenous HGH, sermorelin & older GHRPs (why they're passed over) in this observational study publication.

Provocative growth hormone (GH) stimulation testing is used to evaluate short stature and growth failure in children.

Why It Was Studied

Agents commonly used for testing include clonidine, arginine and glucagon.

This study was designed to estimate the incidence of both microscopic and macroscopic hematuria following GH testing with different provocative agents.

Who Took Part

PubMed indexes the participants as young children, children and teenagers, both men and women.

Subjects undergoing GH stimulation testing were invited to participate in the study.

The subjects performed urine testing at home on days 1, 2, 3 and 7 following GH stimulation studies.

How the Study Was Run

Prior to testing, vital signs were measured and baseline point-of-care (POC) urinalysis was done.

Families notified the study team with any positive findings and returned the data collection tool by mail.

What Was Measured

Agents commonly used for testing include clonidine, arginine and glucagon.

This study was designed to estimate the incidence of both microscopic and macroscopic hematuria following GH testing with different provocative agents.

The subject headings attached to it are Cross-Sectional Studies, Diagnostic Techniques, Endocrine, Growth Disorders, Hematuria, Human Growth Hormone, Prognosis and Stimulation, Chemical.

Author keywords: arginine, clonidine, growth hormone deficiency, pediatric and short stature.

What This Means in Plain Language

This is an observational study of Exogenous HGH, sermorelin & older GHRPs (why they're passed over).

Its findings take up roughly 7 sentences of the abstract and are left out here on purpose; the source paper is the place to read them.

The publication is from 2018 (Journal of pediatric endocrinology & metabolism : JPEM), a journal based in Germany.

More context: the Exogenous HGH, sermorelin & older GHRPs (why they're passed over) compound page, all human trials.

Our Notes on the Compound

Exogenous HGH, sermorelin & older GHRPs (why they're passed over): Constant levels suppress the body's own GHRH, raise somatostatin and dull pituitary response.

Exogenous HGH, sermorelin & older GHRPs (why they're passed over) in the library

Source: PubMed record. This explanation is written by PeptideWhiz from the public record. For research and education only. Not medical advice; no dosing information is given.