A genetic variant in the cytochrome P450 family 2 subfamily R member 1 determines response to vitamin D supplementation.

What Was Tested

This randomized controlled trial looks at Vitamin D, K2, Magnesium and Zinc.

Globally, about 1 billion people have inadequate levels of serum vitamin D and it is prevalent in all ethnicities and age groups.

Few foods naturally contain sufficient vitamin D; therefore, most people get their requirements through supplementation.

Who Took Part

By PubMed's age tags, the people studied were children and teenagers, women only.

How the Study Was Run

The design is described as randomized.

The participants were allocated by chance, so the Vitamin D, K2, Magnesium and Zinc group and the comparison group should start out alike.

The genotypes of the CYP2R1 variant (rs10766197) were identified using TaqMan genotyping assays.

What Was Measured

Globally, about 1 billion people have inadequate levels of serum vitamin D and it is prevalent in all ethnicities and age groups.

Hence vitamin D status is affected by genetic and environmental determinants including season of measurement, diet habitual, health status, body mass index and concurrent medication.

Topics PubMed links to this paper include Cluster Analysis, Cytochrome P450 Family 2, Dietary Supplements, Genetic Predisposition to Disease, Genetic Variation, Iran and Polymorphism, Single Nucleotide.

Author keywords: 25(OH)D, CYP1R2, Supplementation and rs10766197.

What This Means in Plain Language

The paper is a randomized study of Vitamin D, K2, Magnesium and Zinc.

The abstract goes on to report its results in about 7 sentences; this page does not restate them, so read the paper for the findings and their limits.

The publication is from 2019 (Clinical nutrition (Edinburgh, Scotland)), a journal based in England.

More context: the Vitamin D, K2, Magnesium and Zinc compound page, all human trials.