Vitamin D Supplementation in Elderly Black Women Does Not Prevent Bone Loss: A Randomized Controlled Trial.

Plain-language guide to PMID 29905969 (2018): randomized controlled trial of Vitamin D, K2, Magnesium and Zinc in 260 women.

Key Facts

PMID: 29905969
Journal: Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research
Year: 2018
Study type: Randomized Controlled Trial
Authors: Aloia J et al. (10 authors)
DOI: 10.1002/jbmr.3521
Registered trial: NCT01153568

What This Study Did, in Plain Language

What Was Tested

This randomized controlled trial looks at Vitamin D, K2, Magnesium and Zinc.

There is controversy over whether they should be screened for vitamin D deficiency and have higher vitamin D requirements than recommended by the Institute of Medicine (IOM).

The study was conducted in an ambulatory clinical research center.

Who Took Part

According to the abstract, 260 women were involved.

PubMed indexes the participants as older adults, women only.

A total of 260 healthy black American women, 60 years of age and older were recruited to take part in a two-arm, double-dummy 3-year randomized controlled trial (RCT) of vitamin D3 versus placebo.

How the Study Was Run

The design is described as randomized and placebo-controlled.

Random assignment meant chance, not the researchers, decided who got Vitamin D, K2, Magnesium and Zinc and who got the comparison, which limits bias.

The comparison arm used a placebo, so changes seen with Vitamin D, K2, Magnesium and Zinc could be set against what happens without it.

Bone mineral density (BMD) and serum were measured for parathyroid hormone (PTH), C-terminal crosslink telopeptide (CTX), and bone-specific alkaline phosphatase (BSAP) every 6 months.

What Was Measured

The subject headings attached to it are Black or African American, Bone Density, Bone Resorption, Dietary Supplements, Fibroblast Growth Factor-23 and Vitamin D.

Author keywords: ANALYSIS/QUANTITATION OF BONE, BIOCHEMICAL MARKERS OF BONE TURNOVER, BONE MODELING AND REMODELING, CELL/TISSUE SIGNALING, CLINICAL TRIALS and DISEASES AND DISORDERS OF/RELATED TO BONE.

What This Means in Plain Language

The paper is a randomized and placebo-controlled study of Vitamin D, K2, Magnesium and Zinc in 260 women.

The publication is from 2018 (Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research), a journal based in England.

More context: the Vitamin D, K2, Magnesium and Zinc compound page, all human trials.

Our Notes on the Compound

Vitamin D, K2, Magnesium and Zinc: Magnesium is described as required for AMPK to function.

Vitamin D, K2, Magnesium and Zinc in the library

Source: PubMed record. This explanation is written by PeptideWhiz from the public record. For research and education only. Not medical advice; no dosing information is given.