Effects of vitamin D supplementation on metabolic and endocrine parameters in PCOS: a randomized-controlled trial.

What Was Tested

The paper reports a study of Vitamin D, K2, Magnesium and Zinc in the context of pcos, published as a randomized controlled trial.

Therefore, the researchers aimed to investigate the effects of vitamin D supplementation on plasma glucose area under the curve (AUCgluc, primary outcome measure) and on other metabolic and endocrine parameters (secondary outcome measures).

Who Took Part

PubMed indexes the participants as adults, women only.

How the Study Was Run

The researchers set it up as a randomized, double-blind and placebo-controlled study.

The participants were allocated by chance, so the Vitamin D, K2, Magnesium and Zinc group and the comparison group should start out alike.

Neither the participants nor the staff measuring them knew who was on Vitamin D, K2, Magnesium and Zinc, so expectations could not easily colour the readings.

The comparison arm used a placebo, so changes seen with Vitamin D, K2, Magnesium and Zinc could be set against what happens without it.

This study was a single-center, double-blind, randomized placebo-controlled trial conducted between December 2011 and July 2017 at the Medical University of Graz, Austria.

Primary outcome was the between-group difference in AUCgluc at study end while adjusting for baseline values.

What Was Measured

The subject headings attached to it are Austria, Blood Glucose, Cholecalciferol, Dietary Supplements, Insulin, Insulin Resistance and Polycystic Ovary Syndrome.

The authors tagged it with the keywords Glucose sensitivity, PCOS, RCT and Vitamin D supplementation.

What This Means in Plain Language

The paper is a randomized, double-blind and placebo-controlled study of Vitamin D, K2, Magnesium and Zinc in people with pcos.

Its findings take up roughly 4 sentences of the abstract and are left out here on purpose; the source paper is the place to read them.

The publication is from 2019 (European journal of nutrition), a journal based in Germany.

More context: the Vitamin D, K2, Magnesium and Zinc compound page, PCOS research.