Vitamin D and Inflammatory Bowel Disease: Mendelian Randomization Analyses in the Copenhagen Studies and UK Biobank.

What Was Tested

Researchers studied Vitamin D, K2, Magnesium and Zinc in this observational study publication.

Vitamin D may be a modifiable risk factor for inflammatory bowel disease (IBD).

Who Took Part

The study group was 120,013 individuals.

The age groups tagged for this paper are middle-aged adults and older adults, both men and women.

The researchers used a Mendelian randomization design to study 120,013 individuals from the Copenhagen City Heart Study, the Copenhagen General Population Study, and a Copenhagen-based cohort of patients with IBD.

The researchers identified 653 cases of CD and 1265 cases of UC, of which 58 and 113, respectively, had 25-hydroxyvitamin D measurements available.

How the Study Was Run

The researchers also included genetic data from 408,455 individuals from the UK Biobank, including 1707 CD cases and 3147 UC cases.

What Was Measured

PubMed files the paper under topics including Biological Specimen Banks, Cholestanetriol 26-Monooxygenase, Colitis, Ulcerative, Crohn Disease, Cross-Sectional Studies, Cytochrome P450 Family 2 and Denmark.

What This Means in Plain Language

This is an observational study of Vitamin D, K2, Magnesium and Zinc in 120,013 individuals.

With several hundred people or more, it is a fairly large study for this kind of research.

The abstract goes on to report its results in about 5 sentences; this page does not restate them, so read the paper for the findings and their limits.

The publication is from 2018 (The Journal of clinical endocrinology and metabolism), a journal based in United States.

More context: the Vitamin D, K2, Magnesium and Zinc compound page, all human trials.