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Efficacy of GnRH agonist trigger in women having history of follicular-endometrial asynchrony with clomiphene/IUI cycles in unexplained infertility
Plain-language guide to PMID 29955952 (2018): observational study of hCG (human chorionic gonadotropin) in 631 women, endometriosis.
Key Facts
- PMID
- 29955952
- Journal
- Archives of gynecology and obstetrics
- Year
- 2018
- Study type
- Observational Study
- Authors
- Bathwal S et al. (6 authors)
- DOI
- 10.1007/s00404-018-4834-1
What This Study Did, in Plain Language
What Was Tested
This observational study looks at hCG (human chorionic gonadotropin) in the context of endometriosis.
An alternative option to human chorionic gonadotropin (hCG) is GnRH agonist (GnRH-a) for ovulation trigger in intrauterine insemination (IUI) cycles.
Who Took Part
According to the abstract, 631 women were involved.
The age groups tagged for this paper are adults, women only.
This prospective observational study recruited 631 women with unexplained infertility and follicular-endometrial asynchrony (follicle ≥ 18 mm, endometrial thickness (ET) < 7 mm) in previous two failed clomiphene/IUI cycles.
Overall 27 patients with synchronized follicular-endometrial relationship and 49 women with persistent ET < 7 mm and/or follicle > 26 mm were excluded.
How the Study Was Run
Remaining women (n = 555) were divided into two groups: Group A (n = 285) received GnRH-a and Group B (n = 270) received hCG ovulation trigger.
Finally, 513 patients, who underwent IUI, were analysed.
What Was Measured
The subject headings attached to it are Chorionic Gonadotropin, Clomiphene, Endometrium, Gonadotropin-Releasing Hormone, Infertility, Insemination, Artificial and Ovarian Follicle.
The authors tagged it with the keywords Follicular–endometrial asynchrony, GnRH agonist, Ovulation trigger, Unexplained infertility and hCG.
What This Means in Plain Language
This is an observational study of hCG (human chorionic gonadotropin) in 631 women in people with endometriosis.
With several hundred people or more, it is a fairly large study for this kind of research.
The abstract goes on to report its results in about 4 sentences; this page does not restate them, so read the paper for the findings and their limits.
The publication is from 2018 (Archives of gynecology and obstetrics), a journal based in Germany.
More context: the hCG (human chorionic gonadotropin) compound page, Endometriosis research.
Our Notes on the Compound
hCG (human chorionic gonadotropin): An LH analog that drives Leydig-cell testosterone production.
Related Pages
Source: PubMed record. This explanation is written by PeptideWhiz from the public record. For research and education only. Not medical advice; no dosing information is given.