Rate of appearance of amino acids after a meal regulates insulin and glucagon secretion in patients with type 2 diabetes: a randomized clinical trial

What Was Tested

This randomized controlled trial paper looks at Glucagon.

The aim of this study was to test effects of isolated pea protein-based (PP) compared with casein protein-based (CP) meals differing in amino acid compositions on endocrine responses to meal tolerance tests (MTTs) in patients with T2D.

Why It Was Studied

Meal composition regulates the postprandial response of pancreatic and gastrointestinal hormones and plays an important role in patients with type 2 diabetes (T2D).

Proteins have glucagon and insulinotropic effects, which may differ depending on amino acid composition, form of intake, and rate of digestibility and absorption.

Who Took Part

The age groups tagged for this paper are middle-aged adults and older adults, both men and women.

How the Study Was Run

The researchers set it up as a randomized study.

Random assignment meant chance, not the researchers, decided who got Glucagon and who got the comparison, which limits bias.

MTTs were performed at study onset and after 6 wk.

What Was Measured

Meal composition regulates the postprandial response of pancreatic and gastrointestinal hormones and plays an important role in patients with type 2 diabetes (T2D).

Topics PubMed links to this paper include Amino Acids, Blood Glucose, Diabetes Mellitus, Type 2, Diet, High-Protein, Gastric Inhibitory Polypeptide, Glucagon and Glucagon-Like Peptide 1.

What This Means in Plain Language

The paper is a randomized study of Glucagon.

Results are reported in around 9 sentences of the abstract; we leave them to the paper itself rather than summarise them.

The publication is from 2018 (The American journal of clinical nutrition), a journal based in United States.

More context: the Glucagon compound page, all human trials.