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Effect of Maternal Vitamin B12 Supplementation on Cognitive Outcomes in South Indian Children: A Randomized Controlled Clinical Trial
Plain-language guide to PMID 30003521 (2019): placebo-controlled randomized controlled trial study of Cyanocobalamin (Vitamin B12) in 218 children.
Key Facts
- PMID
- 30003521
- Journal
- Maternal and child health journal
- Year
- 2019
- Study type
- Randomized Controlled Trial
- Authors
- Thomas S et al. (8 authors)
- DOI
- 10.1007/s10995-018-2605-z
What This Study Did, in Plain Language
What Was Tested
The paper reports a study of Cyanocobalamin (Vitamin B12), published as a randomized controlled trial.
Objectives To examine the effects of oral maternal vitamin B12 supplementation during pregnancy and early lactation on cognitive development in children.
Why It Was Studied
The association of maternal sociodemographic characteristics, maternal biochemical status during pregnancy, birth weight and home environment with each sub-domain of BSID-III was examined using linear regression analysis.
Separate multiple linear regression analyses for each of the BSID-III sub-domains with maternal trimester specific nutritional biomarker status was conducted.
Who Took Part
The study group was 218 children.
The age groups tagged for this paper are infants and children, both men and women.
Cognitive functions were assessed at 30 months using the Bayley Scales of Infant Development- 3rd edition (BSID III).
How the Study Was Run
The design is described as randomized and placebo-controlled.
Because people in this Cyanocobalamin (Vitamin B12) study were split into groups at random, differences between the groups are less likely to reflect who happened to join each one.
The comparison arm used a placebo, so changes seen with Cyanocobalamin (Vitamin B12) could be set against what happens without it.
What Was Measured
The subject headings attached to it are Child Development, Cognition, Dietary Supplements, Fetal Development, India, Maternal Nutritional Physiological Phenomena and Postnatal Care.
Author keywords: Elevated homocysteine levels and Vitamin B12 supplementation.
What This Means in Plain Language
The paper is a randomized and placebo-controlled study of Cyanocobalamin (Vitamin B12) in 218 children.
The publication is from 2019 (Maternal and child health journal), a journal based in United States.
More context: the Cyanocobalamin (Vitamin B12) compound page, all human trials.
Our Notes on the Compound
Cyanocobalamin (Vitamin B12): A synthetic form of vitamin B12 (cobalamin), an essential nutrient for DNA synthesis, red blood cell formation and neurological function.
Related Pages
Source: PubMed record. This explanation is written by PeptideWhiz from the public record. For research and education only. Not medical advice; no dosing information is given.