Association of vitamin D deficiency with an increased risk of late-onset neonatal sepsis.

What Was Tested

This observational study looks at Vitamin D, K2, Magnesium and Zinc.

A prospective observational study was conducted at a tertiary care Paediatric teaching hospital in northern India to assess vitamin D deficiency as a possible risk factor for late-onset sepsis (LOS) in term and late preterm neonates and also to examine the correlation between maternal and infant vitamin D levels during the neonatal period.

Who Took Part

PubMed tags the participants as both men and women.

Late-onset sepsis (LOS) was defined as the development of signs and symptoms of severe sepsis after 72 h of life and a positive sepsis screen.

Matched controls were recruited from otherwise healthy neonates admitted with physiological hyperbilirubinaemia.

How the Study Was Run

All term and late preterm neonates admitted with LOS between September 2015 and February 2016 who had not been previously admitted for >48 h and had not been prescribed antibiotics or vitamin D were included in the study.

Serum 25(OH) vitamin D was assessed in neonates in both groups and their mothers.

What Was Measured

Topics PubMed links to this paper include Hospitals, Teaching, India, Late Onset Disorders, Neonatal Sepsis, Risk Assessment, Tertiary Care Centers and Vitamin D Deficiency.

Author keywords: 25(OH) vitamin D and immunomodulation.

What This Means in Plain Language

This is an observational study of Vitamin D, K2, Magnesium and Zinc.

Results are reported in around 7 sentences of the abstract; we leave them to the paper itself rather than summarise them.

The publication is from 2018 (Paediatrics and international child health), a journal based in England.

More context: the Vitamin D, K2, Magnesium and Zinc compound page, all human trials.