VITAMIN D RECEPTOR GENE MUTATIONS AND VITAMIN D SERUM LEVELS IN ASTHMATIC CHILDREN.

What Was Tested

Researchers studied Vitamin D, K2, Magnesium and Zinc in this observational study publication.

To verify the relationship between polymorphisms of the vitamin D receptor gene (VDR), clinical findings, and serum vitamin D (VD) levels in asthmatics.

Who Took Part

According to the abstract, 77 children were involved.

By PubMed's age tags, the people studied were children and teenagers, both men and women.

A cross sectional study of 77 children aged 7 to 14 years old, who were attended at a specialized clinic.

The children were divided into 3 groups: asthmatics who had been using inhaled corticosteroids (ICS) for more than one year; asthmatics who had not been using ICS; non-asthmatics, and children without allergies (according to the International Study of Asthma and Allergies in Childhood -- ISAAC).

How the Study Was Run

Spirometry, skin prick tests, the presence of a VDR promoter CDX2 polymorphism from an allele-specific polimerase chain reaction (PCR), exons 2 and 3 polymorphisms genotyping by PCR-SSCA (single-strand conformational analysis), total immunoglobulin E (IgE) and specific IgE to mites and grass were evaluated in these three groups.

Levels of 25-hydroxyvitamin D were determined in asthmatics only.

What Was Measured

The subject headings attached to it are Adrenal Cortex Hormones, Asthma, Calcium, Cross-Sectional Studies, Mutation, Polymorphism, Genetic and Receptors, Calcitriol.

What This Means in Plain Language

This is an observational study of Vitamin D, K2, Magnesium and Zinc in 77 children.

Its findings take up roughly 9 sentences of the abstract and are left out here on purpose; the source paper is the place to read them.

The publication is from 2018 (Revista paulista de pediatria : orgao oficial da Sociedade de Pediatria de Sao Paulo), a journal based in Brazil.

More context: the Vitamin D, K2, Magnesium and Zinc compound page, all human trials.