Intranasal Vasopressin Relieves Orthopedic Pain After Surgery

What Was Tested

This randomized controlled trial paper looks at Vasopressin.

This study investigated the effect of intranasal AVP on orthopedic pain after surgery in a randomized controlled trial with a double-blind design.

Why It Was Studied

Orthopedic pain after surgery is very common and difficult to manage.

Although intranasal arginine vasopressin (AVP) relieves headache (tension-type headache and migraine mostly), the effect of intranasal AVP on the orthopedic pain after surgery is unknown.

Who Took Part

The abstract describes 653 patients taking part.

PubMed indexes the participants as teenagers, adults, middle-aged adults and older adults, both men and women.

The study included 653 orthopedic patients and 661 health volunteers.

How the Study Was Run

In design terms this was a randomized and double-blind study.

Because people in this Vasopressin study were split into groups at random, differences between the groups are less likely to reflect who happened to join each one.

As a double-blind Vasopressin study, the assignments were hidden from both participants and investigators until the end.

Orthopedic pain was analyzed by the visual analogue scales (VAS) and AVP concentration was determined by radioimmunoassay.

What Was Measured

Topics PubMed links to this paper include China, Orthopedics, Pain Management, Postoperative Complications and Vasopressins.

What This Means in Plain Language

The paper is a randomized and double-blind study of Vasopressin in 653 patients.

With several hundred people or more, it is a fairly large study for this kind of research.

Its findings take up roughly 1 sentences of the abstract and are left out here on purpose; the source paper is the place to read them.

The publication is from 2019 (Pain management nursing : official journal of the American Society of Pain Management Nurses), a journal based in United States.

More context: the Vasopressin compound page, all human trials.