Three-monthly bolus vitamin D supplements (1000 vs /day) for prevention of bone loss in children with difficult-to-treat nephrotic syndrome: a randomised clinical trial.

What Was Tested

Researchers studied Vitamin D, K2, Magnesium and Zinc in this randomized controlled trial publication.

Nephrotic syndrome (NS) in children is one of the most common chronic diseases with a remitting and relapsing course.

BMC, bone mineral content; BMD, bone mineral density; DEXA, dual energy X-ray absorptiometry; DTNS, difficult-to-treat nephrotic syndrome; FRNS, frequently relapsing nephrotic syndrome; IFRNS, infrequently relapsing nephrotic syndrome; iPTH, intact parathyroid hormone; NS, nephrotic syndrome; SDNS, steroid-dependent nephrotic syndrome; SRNS steroid-resistant nephrotic syndrome.

Who Took Part

The abstract describes 60 children taking part.

PubMed indexes the participants as infants, young children, children and teenagers, both men and women.

How the Study Was Run

The design is described as randomized, open-label and parallel-group.

Because people in this Vitamin D, K2, Magnesium and Zinc study were split into groups at random, differences between the groups are less likely to reflect who happened to join each one.

Nothing was hidden in this open-label Vitamin D, K2, Magnesium and Zinc study: the children and staff both knew the treatment.

The Vitamin D, K2, Magnesium and Zinc group and the comparison group ran side by side rather than switching.

What Was Measured

The subject headings attached to it are Bone Diseases, Metabolic, Glucocorticoids, Nephrotic Syndrome and Vitamin D.

The authors tagged it with the keywords calcium, osteoprotection and prednisolone.

What This Means in Plain Language

The paper is a randomized, open-label and parallel-group study of Vitamin D, K2, Magnesium and Zinc in 60 children.

Results are reported in around 11 sentences of the abstract; we leave them to the paper itself rather than summarise them.

The publication is from 2018 (Paediatrics and international child health), a journal based in England.

More context: the Vitamin D, K2, Magnesium and Zinc compound page, all human trials.