Antenatal Magnesium Sulfate Exposure and Ponderal Index in Preterm Infants.

What Was Tested

The paper reports a study of Vitamin D, K2, Magnesium and Zinc, published as a randomized controlled trial.

Antenatal magnesium sulfate (MgSO4) is known to affect the central nervous system of preterm infants, and there is biologic rationale for influence on other phenotypes.

This study investigated the effect of MgSO4 exposure on the trajectory of ponderal index (PI, kg/m3) from birth to 2 years of age.

Multivariable logistic regression was used to assess the relationship between PI from birth to 2 years of age and exposure to MgSO4 versus placebo.

Who Took Part

By PubMed's age tags, the people studied were infants and young children, both men and women.

A secondary analysis of a U.S. randomized controlled trial investigating MgSO4 versus placebo administration among women at high risk for preterm delivery was performed.

How the Study Was Run

The design is described as randomized and placebo-controlled.

The participants were allocated by chance, so the Vitamin D, K2, Magnesium and Zinc group and the comparison group should start out alike.

A placebo (an inactive look-alike) gave the Vitamin D, K2, Magnesium and Zinc group a baseline to be compared against.

What Was Measured

Topics PubMed links to this paper include Infant, Premature, Logistic Models, Magnesium Sulfate, Prenatal Exposure Delayed Effects, Sex Factors, Tocolytic Agents and Weight Gain.

What This Means in Plain Language

The paper is a randomized and placebo-controlled study of Vitamin D, K2, Magnesium and Zinc.

Results are reported in around 5 sentences of the abstract; we leave them to the paper itself rather than summarise them.

The publication is from 2019 (American journal of perinatology), a journal based in United States.

More context: the Vitamin D, K2, Magnesium and Zinc compound page, all human trials.