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Vitamin D supplementation improves waist-to-hip ratio and fasting blood glucose in vitamin D deficient, overweight or obese Asians: A pilot secondary analysis of a randomised controlled trial.
Plain-language guide to PMID 30321667 (2019): randomized controlled trial of Vitamin D, K2, Magnesium and Zinc in 65 participants.
Key Facts
- PMID
- 30321667
- Journal
- The Journal of steroid biochemistry and molecular biology
- Year
- 2019
- Study type
- Randomized Controlled Trial
- Authors
- Scott D et al. (6 authors)
- DOI
- 10.1016/j.jsbmb.2018.10.006
- Registered trial
- NCT02112721
What This Study Did, in Plain Language
What Was Tested
The paper reports a study of Vitamin D, K2, Magnesium and Zinc, published as a randomized controlled trial.
Primary outcome was change in insulin sensitivity (M-value) assessed by hyperinsulinemic-euglycemic clamp.
Secondary outcomes were changes in 25(OH)D (chemiluminescent immunoassay), fasting blood glucose (YSI Stat 2300), and body composition including waist-hip ratio and total body fat percentage (dual-energy X-ray absorptiometry).
Who Took Part
The study group was 65 participants.
By PubMed's age tags, the people studied were young adults and adults, both men and women.
How the Study Was Run
In design terms this was a randomized, placebo-controlled and pilot study.
Because people in this Vitamin D, K2, Magnesium and Zinc study were split into groups at random, differences between the groups are less likely to reflect who happened to join each one.
Some participants received a placebo instead of Vitamin D, K2, Magnesium and Zinc, giving a reference point.
It is described as a pilot, a small early test of whether a larger Vitamin D, K2, Magnesium and Zinc study would be practical.
What Was Measured
Primary outcome was change in insulin sensitivity (M-value) assessed by hyperinsulinemic-euglycemic clamp.
Secondary outcomes were changes in 25(OH)D (chemiluminescent immunoassay), fasting blood glucose (YSI Stat 2300), and body composition including waist-hip ratio and total body fat percentage (dual-energy X-ray absorptiometry).
Topics PubMed links to this paper include Asian People, Blood Glucose, Fasting, Obesity, Overweight, Vitamin D and Vitamin D Deficiency.
The authors tagged it with the keywords Body composition, Insulin and Supplementation.
What This Means in Plain Language
The paper is a randomized, placebo-controlled and pilot study of Vitamin D, K2, Magnesium and Zinc in 65 participants.
The publication is from 2019 (The Journal of steroid biochemistry and molecular biology), a journal based in England.
More context: the Vitamin D, K2, Magnesium and Zinc compound page, all human trials.
Our Notes on the Compound
Vitamin D, K2, Magnesium and Zinc: Magnesium is described as required for AMPK to function.
Related Pages
Source: PubMed record. This explanation is written by PeptideWhiz from the public record. For research and education only. Not medical advice; no dosing information is given.