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Cognition and Vitamin D in Older African-American Women- Physical performance and Osteoporosis prevention with vitamin D in older African Americans Trial and Dementia.

Plain-language guide to PMID 30359476 (2019): double-blind randomized controlled trial of Vitamin D, K2, Magnesium and Zinc.

Key Facts

PMID
30359476
Journal
Journal of the American Geriatrics Society
Year
2019
Study type
Randomized Controlled Trial
Authors
Owusu JE et al. (11 authors)
DOI
10.1111/jgs.15607

What This Study Did, in Plain Language

What Was Tested

Researchers studied Vitamin D, K2, Magnesium and Zinc in this randomized controlled trial publication.

Who Took Part

By PubMed's age tags, the people studied were older adults and people over 80, women only.

Cognitive assessments every 6 months using the Mini-Mental State Examination (MMSE) to detect cognitive decline.

How the Study Was Run

The design is described as randomized, double-blind and placebo-controlled.

Random assignment meant chance, not the researchers, decided who got Vitamin D, K2, Magnesium and Zinc and who got the comparison, which limits bias.

Blinding on both sides kept the participants and researchers unaware of who received Vitamin D, K2, Magnesium and Zinc.

Some participants received a placebo instead of Vitamin D, K2, Magnesium and Zinc, giving a reference point.

Randomized, double-blind, placebo-controlled clinical trial.

Bone Mineral Research Center at New York University Winthrop Hospital.

Mean MMSE scores were calculated over time for both groups.

Those with MMSE scores less than 21 at baseline were excluded.

What Was Measured

PubMed files the paper under topics including Black or African American, Cholecalciferol, Cognition, Cognitive Dysfunction, Dementia, Dietary Supplements and Healthy Volunteers.

Author keywords: calcium and vitamin D.

What This Means in Plain Language

The paper is a randomized, double-blind and placebo-controlled study of Vitamin D, K2, Magnesium and Zinc.

Its findings take up roughly 7 sentences of the abstract and are left out here on purpose; the source paper is the place to read them.

The publication is from 2019 (Journal of the American Geriatrics Society), a journal based in United States.

More context: the Vitamin D, K2, Magnesium and Zinc compound page, all human trials.

Our Notes on the Compound

Vitamin D, K2, Magnesium and Zinc: Magnesium is described as required for AMPK to function.

Related Pages

Source: PubMed record. This explanation is written by PeptideWhiz from the public record. For research and education only. Not medical advice; no dosing information is given.