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Profiles of peptide YY and ghrelin, levels of hunger and satiety, and ad libitum intake in obese and non-obese Indonesian women

Plain-language guide to PMID 30375352 (2019): open-label clinical study of Peptide YY and Ghrelin.

Key Facts

PMID
30375352
Journal
Romanian journal of internal medicine = Revue roumaine de medecine interne
Year
2019
Study type
Clinical Study
Authors
Witjaksono F et al. (5 authors)
DOI
10.2478/rjim-2018-0027

What This Study Did, in Plain Language

What Was Tested

Researchers studied Peptide YY and Ghrelin in this clinical study publication.

The current study aimed to assess profiles of peptide YY and ghrelin, visual analog scales (VAS) for hunger and satiety, and ad libitum intake in obese and non-obese women.

Who Took Part

By PubMed's age tags, the people studied were adults, women only.

This open-label non-randomized interventional study involved obese (BMI ≥ 25-35 kg/m2) and non-obese (BMI 18.5-23.0 kg/m2) women subjects.

How the Study Was Run

The researchers set it up as an open-label study.

Being open-label, the Peptide YY study did not mask who received what.

Levels of peptide YY and ghrelin were determined by radioimmunoassay and enzyme-linked immunosorbent assay (ELISA), respectively, while the degrees of hunger and satiety were measured using visual analog scale (VAS) questionnaires.

The results were compared in fasting condition and in 15, 60, 120, and 180 minutes after breakfast with balance composition formulation.

What Was Measured

The subject headings attached to it are Area Under Curve, Ghrelin, Hunger, Indonesia, Insulin Resistance, Obesity and Peptide YY.

The authors tagged it with the keywords food intake and satiation.

What This Means in Plain Language

The paper is an open-label study of Peptide YY and Ghrelin.

Its findings take up roughly 4 sentences of the abstract and are left out here on purpose; the source paper is the place to read them.

The publication is from 2019 (Romanian journal of internal medicine = Revue roumaine de medecine interne), a journal based in Germany.

More context: the Peptide YY compound page and the Ghrelin compound page, all human trials.

Our Notes on the Compounds

Peptide YY: A 36-amino-acid gut hormone released after eating that is studied for its role in appetite.

Ghrelin: A 28-amino-acid stomach hormone that signals hunger and triggers growth hormone release; studied in human trials as an infusion.

Related Pages

Source: PubMed record. This explanation is written by PeptideWhiz from the public record. For research and education only. Not medical advice; no dosing information is given.