Effect of Vitamin D Supplementation on Depressive Symptoms in Patients With Knee Osteoarthritis.

What Was Tested

Researchers studied Vitamin D, K2, Magnesium and Zinc in this randomized controlled trial publication.

To determine the effect of vitamin D supplementation and maintaining sufficient serum vitamin D on depressive symptoms in patients with knee osteoarthritis (OA) and vitamin D deficiency.

Multilevel mixed-effect models were used to compare differences of change in PHQ-9 scores between groups.

Who Took Part

PubMed indexes the participants as middle-aged adults and older adults, both men and women.

This clinical trial was conducted in participants with symptomatic knee OA and vitamin D deficiency from June 2010 to December 2013 in Tasmania and Victoria, Australia.

How the Study Was Run

The design is described as randomized, double-blind, placebo-controlled and multicenter.

The participants were allocated by chance, so the Vitamin D, K2, Magnesium and Zinc group and the comparison group should start out alike.

As a double-blind Vitamin D, K2, Magnesium and Zinc study, the assignments were hidden from both participants and investigators until the end.

The comparison arm used a placebo, so changes seen with Vitamin D, K2, Magnesium and Zinc could be set against what happens without it.

More than one site took part, so the participants came from several places.

A prespecified secondary analysis of a multicentre, randomized, double-blind, placebo-controlled trial.

What Was Measured

The subject headings attached to it are Australia, Depression, Dietary Supplements, Osteoarthritis, Knee, Prevalence, Self Report and Vitamin D.

The authors tagged it with the keywords Vitamin D supplementation, depressive symptoms and vitamin D deficiency.

What This Means in Plain Language

The paper is a randomized, double-blind and placebo-controlled study of Vitamin D, K2, Magnesium and Zinc.

Its findings take up roughly 4 sentences of the abstract and are left out here on purpose; the source paper is the place to read them.

The publication is from 2019 (Journal of the American Medical Directors Association), a journal based in United States.

More context: the Vitamin D, K2, Magnesium and Zinc compound page, all human trials.