Study of glutathione S-transferase levels in patients receiving intravenous paracetamol perioperatively: A randomized controlled trial.

What Was Tested

Researchers studied Glutathione in this randomized controlled trial publication.

Many studies have analyzed the effect of paracetamol on liver functions.

The aim of this study was to measure glutathione S-transferase (GST) concentrations in patients receiving intravenous (IV) paracetamol infusions as part of their perioperative pain relief regimen to assess its effect on hepatocellular integrity.

Who Took Part

PubMed indexes the participants as teenagers, young adults, adults and middle-aged adults, both men and women.

Patients between the ages of 18 and 60 years of both sexes, of American Society of Anesthesiologists (ASA) grades 1 and 2, undergoing laparoscopic gastrointestinal (GI) surgeries were included in the study.

Patients in the paracetamol group received IV paracetamol at identical time points.

How the Study Was Run

In design terms this was a randomized, double-blind and placebo-controlled study.

The participants were allocated by chance, so the Glutathione group and the comparison group should start out alike.

Blinding on both sides kept the participants and researchers unaware of who received Glutathione.

The comparison arm used a placebo, so changes seen with Glutathione could be set against what happens without it.

Blood samples were collected preoperatively, after 1, 6, and at 24 h after induction.

GST levels were measured at baseline and after 1, 6, and 24 h in both the groups.

What Was Measured

PubMed files the paper under topics including Acetaminophen, Biomarkers, Chemical and Drug Induced Liver Injury, Endoscopy, Gastrointestinal, Glutathione Transferase, Laparoscopy and Pain.

Author keywords: Glutathione S-transferase, Intravenous paracetamol, Laparoscopic surgery, Liver enzymes and Subclinical hepatic injury.

What This Means in Plain Language

The paper is a randomized, double-blind and placebo-controlled study of Glutathione.

Its findings take up roughly 6 sentences of the abstract and are left out here on purpose; the source paper is the place to read them.

The publication is from 2018 (Indian journal of gastroenterology : official journal of the Indian Society of Gastroenterology), a journal based in India.

More context: the Glutathione compound page, all human trials.