Pharmacokinetic Interaction Study Between Saxagliptin and Omeprazole, Famotidine, or Magnesium and Aluminum Hydroxides Plus Simethicone in Healthy Subjects: An Open-Label Randomized Crossover Study.

What Was Tested

Researchers studied Vitamin D, K2, Magnesium and Zinc in this randomized controlled trial publication.

Saxagliptin is an orally administered, highly potent, and selective dipeptidyl peptidase-4 inhibitor for the management of type 2 diabetes mellitus.

This was an open-label, randomized, 5-treatment, 5-period, 3-way crossover study in 15 healthy subjects.

Who Took Part

The abstract describes 15 subjects taking part.

By PubMed's age tags, the people studied were young adults and adults, both men and women.

How the Study Was Run

The design is described as randomized, open-label, crossover and parallel-group.

Random assignment meant chance, not the researchers, decided who got Vitamin D, K2, Magnesium and Zinc and who got the comparison, which limits bias.

Everyone knew when Vitamin D, K2, Magnesium and Zinc was being given (open label), which is simpler to run but leaves more room for expectations to affect what is reported.

Each person switched between Vitamin D, K2, Magnesium and Zinc and the comparison at some point, usually with a gap in between.

Groups ran in parallel: each of the subjects stayed in one arm throughout.

What Was Measured

The subject headings attached to it are Adamantane, Aluminum Hydroxide, Area Under Curve, Dipeptides, Drug Combinations, Drug Interactions and Famotidine.

The authors tagged it with the keywords Maalox Max, omeprazole and saxagliptin.

What This Means in Plain Language

The paper is a randomized, open-label and crossover study of Vitamin D, K2, Magnesium and Zinc in 15 subjects.

With fewer than 40 people, it is a small study, so it is better read as an early signal for further research than as a settled answer.

The publication is from 2019 (Clinical pharmacology in drug development), a journal based in United States.

More context: the Vitamin D, K2, Magnesium and Zinc compound page, all human trials.