Effects of Zinc Combined with Probiotics on Antibiotic-associated Diarrhea Secondary to Childhood Pneumonia.

What Was Tested

Researchers studied Vitamin D, K2, Magnesium and Zinc in this randomized controlled trial publication.

The aim of this study was to evaluate the impact of zinc combined with probiotics (Bifico) on antibiotic-associated diarrhea (AAD) secondary to pneumonia.

Who Took Part

The abstract describes 50 patients taking part.

By PubMed's age tags, the people studied were infants and young children, both men and women.

A total of 50 patients with AAD secondary to pneumonia were randomly divided into a probiotics group (Bifico) and a combined group (zinc combined with Bifico) and 25 pneumonia patients without AAD as the control group.

How the Study Was Run

The design is described as randomized.

Random assignment meant chance, not the researchers, decided who got Vitamin D, K2, Magnesium and Zinc and who got the comparison, which limits bias.

Serum levels of zinc, diamine oxidase (DAO) activity, D-lactate and intestinal flora [Bifidobacterium, Escherichia coli and Bifidobacterium/E. coli (B/E) ratio] were detected before and after intervention.

What Was Measured

Topics PubMed links to this paper include Amine Oxidase (Copper-Containing), Anti-Bacterial Agents, Bifidobacterium, Combined Modality Therapy, Diarrhea, Escherichia coli and Gastrointestinal Microbiome.

Author keywords: pneumonia, probiotics and zinc.

What This Means in Plain Language

The paper is a randomized study of Vitamin D, K2, Magnesium and Zinc in 50 patients.

The abstract goes on to report its results in about 3 sentences; this page does not restate them, so read the paper for the findings and their limits.

The publication is from 2019 (Journal of tropical pediatrics), a journal based in England.

More context: the Vitamin D, K2, Magnesium and Zinc compound page, all human trials.