Vitamin D deficiency is associated with higher disease activity and the risk for uveitis in juvenile idiopathic arthritis - data from a German inception cohort.

What Was Tested

Researchers studied Vitamin D, K2, Magnesium and Zinc in this observational study publication.

Who Took Part

The abstract describes 954 patients taking part.

PubMed indexes the participants as young children, children and teenagers, both men and women.

Patients ≤ 16 years of age with recently diagnosed JIA (< 12 months) were enrolled in the inception cohort of patients with newly diagnosed JIA (ICON), an ongoing prospective observational, controlled multicenter study started in 2010.

Of the 954 enrolled patients, 360 patients with two blood samples taken during the first 2 years after inclusion and with follow up of 3 years were selected.

How the Study Was Run

The researchers set it up as a multicenter study.

More than one site took part, so the patients came from several places.

Clinical and laboratory parameters were ascertained quarterly during the first year and half-yearly thereafter.

The serum 25(OH)D levels were determined and compared with those of subjects from the general population after matching for age, sex, migration status and the month of blood-drawing.

What Was Measured

PubMed files the paper under topics including Arthritis, Juvenile, Risk Assessment, Risk Factors, Uveitis, Vitamin D and Vitamin D Deficiency.

Author keywords: Disease activity and Juvenile idiopathic arthritis.

What This Means in Plain Language

The paper is a multicenter study of Vitamin D, K2, Magnesium and Zinc in 954 patients.

With several hundred people or more, it is a fairly large study for this kind of research.

Results are reported in around 4 sentences of the abstract; we leave them to the paper itself rather than summarise them.

The publication is from 2018 (Arthritis research & therapy), a journal based in England.

More context: the Vitamin D, K2, Magnesium and Zinc compound page, all human trials.