← Human Trials & Peer-Reviewed Studies
The Effects of Two New Dual Zinc plus Arginine Dentifrices in Reducing Oral Bacteria in Multiple Locations in the Mouth: 12-Hour Whole Mouth Antibacterial Protection for Whole Mouth Health.
Plain-language guide to PMID 30620868 (2018): double-blind randomized controlled trial of Vitamin D, K2, Magnesium and Zinc.
Key Facts
- PMID
- 30620868
- Journal
- The Journal of clinical dentistry
- Year
- 2018
- Study type
- Randomized Controlled Trial
- Authors
- Prasad KV et al. (6 authors)
What This Study Did, in Plain Language
What Was Tested
The paper reports a study of Vitamin D, K2, Magnesium and Zinc, published as a randomized controlled trial.
Who Took Part
PubMed indexes the participants as adults.
One hundred eighty adult subjects who met inclusion and exclusion criteria and signed an informed consent form were enrolled in the study.
Statistical analyses were performed separately for each sample site using ANOVA and ANCOVA for within- and between-treatment comparisons, respectively.
How the Study Was Run
The researchers set it up as a randomized, double-blind and parallel-group study.
Random assignment meant chance, not the researchers, decided who got Vitamin D, K2, Magnesium and Zinc and who got the comparison, which limits bias.
Blinding on both sides kept the participants and researchers unaware of who received Vitamin D, K2, Magnesium and Zinc.
Groups ran in parallel: each of the participants stayed in one arm throughout.
A randomized, single-center, three-cell, double-blind, parallel-group design was employed.
The study protocol was approved by an Institutional Review Board.
Oral samples were collected from the teeth, tongue, oral buccal mucosa, gingiva, and saliva at baseline and 12 hours after 14 and 29 days of assigned product use and were processed, serially diluted, plated, incubated, and scored for viable bacteria.
What Was Measured
PubMed files the paper under topics including Anti-Bacterial Agents, Arginine, Bacteria, Dentifrices, Fluorides, Mouth and Sodium Fluoride.
Author keywords: antibacterial protection, cheeks, clinical, gingiva, teeth and tongue.
What This Means in Plain Language
The paper is a randomized, double-blind and parallel-group study of Vitamin D, K2, Magnesium and Zinc.
Results are reported in around 6 sentences of the abstract; we leave them to the paper itself rather than summarise them.
The publication is from 2018 (The Journal of clinical dentistry), a journal based in United States.
More context: the Vitamin D, K2, Magnesium and Zinc compound page, all human trials.
Our Notes on the Compound
Vitamin D, K2, Magnesium and Zinc: Magnesium is described as required for AMPK to function.
Related Pages
Source: PubMed record. This explanation is written by PeptideWhiz from the public record. For research and education only. Not medical advice; no dosing information is given.