[Effect of Rhubarb Combined Medicinal Activated Carbon on Levels of Serum Phosphorus, Calci- um-Phosphorus Product, and Parathyroid Hormone in Hemodialysis Patients with Hyperphosphatemia]

Plain-language guide to PMID 30634204 (2016): randomized controlled trial study of Parathyroid Hormone (PTH 1-84) in 126 patients, hyperparathyroidism.

Key Facts

PMID: 30634204
Journal: Zhongguo Zhong xi yi jie he za zhi Zhongguo Zhongxiyi jiehe zazhi = Chinese journal of integrated traditional and Western medicine
Year: 2016
Study type: Randomized Controlled Trial
Authors: Xu Q et al. (7 authors)

What This Study Did, in Plain Language

What Was Tested

The paper reports a study of Parathyroid Hormone (PTH 1-84) in the context of hyperparathyroidism, published as a randomized controlled trial.

Objective To study the effect of rhubarb combined medicinal activated carbon on levels of serum phosphorus and calcium-phosphorus product, as well as parathyroid hormone in hemodi- alysis patients with hyperphosphatemia.

Why It Was Studied

The therapeutic course for all was 8 weeks.

Levels of serum calcium , phosphorus, calcium- phosphorus product and parathyroid hormone were detected in the two groups before treatment, and at week 2, 4, 6, and 8 after treatment.

Who Took Part

The abstract describes 126 patients taking part.

Methods Totally 126 hemodialysis patients with hyperphos- phatemia who had received treatment of calcium containing phosphorus binders were assigned to the treatment group and the control group according to random digit table, 63 in each group.

How the Study Was Run

The researchers set it up as a randomized study.

Random assignment meant chance, not the researchers, decided who got Parathyroid Hormone (PTH 1-84) and who got the comparison, which limits bias.

What Was Measured

Levels of serum calcium , phosphorus, calcium- phosphorus product and parathyroid hormone were detected in the two groups before treatment, and at week 2, 4, 6, and 8 after treatment.

Adverse reactions of gastrointestinal tract were observed as well.

Topics PubMed links to this paper include Calcium, Carbon, Hyperphosphatemia, Kidney Failure, Chronic, Parathyroid Hormone, Phosphorus and Plant Extracts.

What This Means in Plain Language

The paper is a randomized study of Parathyroid Hormone (PTH 1-84) in 126 patients in people with hyperparathyroidism.

The publication is from 2016 (Zhongguo Zhong xi yi jie he za zhi Zhongguo Zhongxiyi jiehe zazhi = Chinese journal of integrated traditional and Western medicine), a journal based in China.

More context: the Parathyroid Hormone (PTH 1-84) compound page, Hyperparathyroidism research.

Our Notes on the Compound

Parathyroid Hormone (PTH 1-84): The 84-amino-acid hormone that raises blood calcium; full-length PTH (Natpara) has been used in hypoparathyroidism. Teriparatide is its 1-34 fragment.

Source: PubMed record. This explanation is written by PeptideWhiz from the public record. For research and education only. Not medical advice; no dosing information is given.