Correlations of insulin resistance and HbA1c with cytokines IGF-1, bFGF and IL-6 in the aqueous humor of patients with diabetic cataract

What Was Tested

The paper reports a study of IGF-1 LR3 in the context of insulin resistance, prediabetes & type 2 diabetes, published as an observational study.

The study aimed to investigate the correlations of insulin resistance and hemoglobin A1c (HbA1c) with cytokines [insulin-like growth factor 1 (IGF-1), basic fibroblast growth factor (bFGF) and interleukin-6 (IL-6)] in the aqueous humor of patients with diabetic cataract.

Who Took Part

The study group was 59 patients.

By PubMed's age tags, the people studied were adults and middle-aged adults, both men and women.

59 patients with diabetic cataract and 58 patients with simple cataract treated in Jining No. 1 People´s Hospital (Jining, China) from January 2017 to February 2018, were selected randomly.

The levels of homeostasis model assessment of insulin resistance (HOMA-IR) and HbAlc, as well as IGF-1, bFGF and IL-6 in the aqueous humor were compared between the two groups.

How the Study Was Run

The correlations of HOMA-IR and HbAlc with IGF-1, bFGF and IL-6 were analyzed.

What Was Measured

Topics PubMed links to this paper include Aqueous Humor, Biomarkers, Case-Control Studies, Cataract, Diabetes Complications, Fibroblast Growth Factor 2 and Glycated Hemoglobin.

What This Means in Plain Language

This is an observational study of IGF-1 LR3 in 59 patients in people with insulin resistance, prediabetes & type 2 diabetes.

Its findings take up roughly 6 sentences of the abstract and are left out here on purpose; the source paper is the place to read them.

The publication is from 2019 (European review for medical and pharmacological sciences), a journal based in United States.

More context: the IGF-1 LR3 compound page, Insulin resistance, prediabetes & type 2 diabetes research.