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Vitamin-D2 treatment-associated decrease in 25(OH)D3 level is a reciprocal phenomenon: a randomized controlled trial.
Plain-language guide to PMID 30658603 (2019): double-blind randomized controlled trial of Vitamin D, K2, Magnesium and Zinc in 97 participants.
Key Facts
- PMID
- 30658603
- Journal
- BMC endocrine disorders
- Year
- 2019
- Study type
- Randomized Controlled Trial
- Authors
- Hammami MM et al. (4 authors)
- DOI
- 10.1186/s12902-019-0337-8
- Registered trial
- NCT03035084
What This Study Did, in Plain Language
What Was Tested
The paper reports a study of Vitamin D, K2, Magnesium and Zinc, published as a randomized controlled trial.
ClinicalTrial.gov identifier: NCT03035084 (registered January 27, 2017).
Who Took Part
According to the abstract, 97 participants were involved.
PubMed indexes the participants as adults, both men and women.
Interventions were concealed from volunteers and research coordinators and blindly-administered.
Results of 97 participants were analyzed.
How the Study Was Run
The researchers set it up as a randomized, double-blind and placebo-controlled study.
The participants were allocated by chance, so the Vitamin D, K2, Magnesium and Zinc group and the comparison group should start out alike.
Blinding on both sides kept the participants and researchers unaware of who received Vitamin D, K2, Magnesium and Zinc.
A placebo (an inactive look-alike) gave the Vitamin D, K2, Magnesium and Zinc group a baseline to be compared against.
Serum 25(OH)D2 and 25(OH)D3 levels were blindly-determined at baseline and days 14, 28, 42, and 56, post-randomization by high performance liquid chromatography assay.
Primary outcome measure was day-28 D2-associated change in 25(OH)D3 level in study-1 and D3-associated change in 25(OH)D2 level in study-2, adjusted for baseline levels.
What Was Measured
The subject headings attached to it are Dietary Supplements, Ergocalciferols, Healthy Volunteers, Seasons, Vitamin D, Vitamin D Deficiency and Vitamins.
The authors tagged it with the keywords 25-hydroxyvitamin D2 level, 25-hydroxyvitamin D3 level, Cholecalciferol treatment and Ergocalciferol treatment.
What This Means in Plain Language
The paper is a randomized, double-blind and placebo-controlled study of Vitamin D, K2, Magnesium and Zinc in 97 participants.
Its findings take up roughly 6 sentences of the abstract and are left out here on purpose; the source paper is the place to read them.
The publication is from 2019 (BMC endocrine disorders), a journal based in England.
More context: the Vitamin D, K2, Magnesium and Zinc compound page, all human trials.
Our Notes on the Compound
Vitamin D, K2, Magnesium and Zinc: Magnesium is described as required for AMPK to function.
Related Pages
Source: PubMed record. This explanation is written by PeptideWhiz from the public record. For research and education only. Not medical advice; no dosing information is given.