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Intramuscular injection, intravenous infusion, and intravenous bolus of oxytocin in the third stage of labor for prevention of postpartum hemorrhage: a three-arm randomized control trial
Plain-language guide to PMID 30658605 (2019): open-label randomized controlled trial study of Oxytocin.
Key Facts
- PMID
- 30658605
- Journal
- BMC pregnancy and childbirth
- Year
- 2019
- Study type
- Randomized Controlled Trial
- Authors
- Charles D et al. (11 authors)
- DOI
- 10.1186/s12884-019-2181-2
What This Study Did, in Plain Language
What Was Tested
Researchers studied Oxytocin in this randomized controlled trial publication.
Oxytocin for postpartum hemorrhage (PPH) prophylaxis is commonly administered by either intramuscular (IM) injection or intravenous (IV) infusion with both routes recommended equally and little discussion of potential differences between the two.
Clinicaltrials.gov # NCT01914419 , posted August 2, 2013.
Who Took Part
By PubMed's age tags, the people studied were adults, women only.
In two tertiary level Egyptian maternity hospitals, women delivering vaginally without exposure to pre-delivery uterotonics were randomized to one of three prophylactic oxytocin administration groups after delivery of the baby.
How the Study Was Run
The researchers set it up as a randomized, open-label and parallel-group study.
The participants were allocated by chance, so the Oxytocin group and the comparison group should start out alike.
Nothing was hidden in this open-label Oxytocin study: the participants and staff both knew the treatment.
The Oxytocin group and the comparison group ran side by side rather than switching.
Blood loss was measured 1 h after delivery, and side effects were recorded.
What Was Measured
The subject headings attached to it are Administration, Intravenous, Delivery, Obstetric, Egypt, Labor Stage, Third, Oxytocics, Oxytocin and Postpartum Hemorrhage.
Author keywords: Bolus oxytocin, Intramuscular oxytocin, Intravenous oxytocin, Oxytocin prophylaxis, Postpartum blood loss and Route of administration.
What This Means in Plain Language
The paper is a randomized, open-label and parallel-group study of Oxytocin.
Its findings take up roughly 6 sentences of the abstract and are left out here on purpose; the source paper is the place to read them.
The publication is from 2019 (BMC pregnancy and childbirth), a journal based in England.
More context: the Oxytocin compound page, all human trials.
Our Notes on the Compound
Oxytocin: A peptide hormone with established obstetric medical uses and a less settled role in research on behavior, sexual function and appetite.
Related Pages
Source: PubMed record. This explanation is written by PeptideWhiz from the public record. For research and education only. Not medical advice; no dosing information is given.