Associations of vitamin D binding protein variants with the vitamin D-induced increase in serum 25-hydroxyvitamin D.

What Was Tested

Researchers studied Vitamin D, K2, Magnesium and Zinc in this randomized controlled trial publication.

The researchers aimed to investigate possible genetic factors that may modify the impact of environmental exposure on vitamin D status.

Why It Was Studied

The candidate gene variant the researchers investigated was the Gc gene-rs4588 polymorphism at the vitamin D receptor (DBP) locus.

Who Took Part

According to the abstract, 619 girls were involved.

By PubMed's age tags, the people studied were children and teenagers, women only.

How the Study Was Run

In design terms this was a randomized study.

Because people in this Vitamin D, K2, Magnesium and Zinc study were split into groups at random, differences between the groups are less likely to reflect who happened to join each one.

The genotypes of the DBP variant (rs4588) were analyzed using the TaqMan genotyping assay.

What Was Measured

Topics PubMed links to this paper include Alleles, Cholecalciferol, Dietary Supplements, Genetic Association Studies, Genetic Predisposition to Disease, Genotype and Iran.

Author keywords: Gc gene, Supplementation, Total 25(OH) D and rs4588.

What This Means in Plain Language

The paper is a randomized study of Vitamin D, K2, Magnesium and Zinc in 619 girls.

With several hundred people or more, it is a fairly large study for this kind of research.

The abstract goes on to report its results in about 6 sentences; this page does not restate them, so read the paper for the findings and their limits.

The publication is from 2019 (Clinical nutrition ESPEN), a journal based in England.

More context: the Vitamin D, K2, Magnesium and Zinc compound page, all human trials.