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The Effect of Vitamin D Supplementation on Hepcidin, Iron Status, and Inflammation in Pregnant Women in the United Kingdom.
Plain-language guide to PMID 30669280 (2019): double-blind randomized controlled trial of Vitamin D, K2, Magnesium and Zinc.
Key Facts
- PMID
- 30669280
- Journal
- Nutrients
- Year
- 2019
- Study type
- Randomized Controlled Trial
- Authors
- Braithwaite VS et al. (7 authors)
- DOI
- 10.3390/nu11010190
What This Study Did, in Plain Language
What Was Tested
This randomized controlled trial looks at Vitamin D, K2, Magnesium and Zinc.
Their aim was to identify whether antenatal vitamin D₃ supplementation affects iron status (via hepcidin suppression) and/or inflammation.
Why It Was Studied
Iron and vitamin D deficiencies are common during pregnancy.
Using a subset of the UK multicenter Maternal Vitamin D Osteoporosis Study (MAVIDOS)-a double-blinded, randomized, placebo-controlled trial (ISRCTN82927713; EudraCT2007-001716-23)-the researchers performed a secondary laboratory analysis.
Who Took Part
By PubMed's age tags, the people studied were young adults and adults, women only.
How the Study Was Run
The design is described as randomized, double-blind, placebo-controlled and multicenter.
Because people in this Vitamin D, K2, Magnesium and Zinc study were split into groups at random, differences between the groups are less likely to reflect who happened to join each one.
Blinding on both sides kept the participants and researchers unaware of who received Vitamin D, K2, Magnesium and Zinc.
A placebo (an inactive look-alike) gave the Vitamin D, K2, Magnesium and Zinc group a baseline to be compared against.
Running at several centres spread the Vitamin D, K2, Magnesium and Zinc study over different clinics and patient groups.
What Was Measured
Using a subset of the UK multicenter Maternal Vitamin D Osteoporosis Study (MAVIDOS)-a double-blinded, randomized, placebo-controlled trial (ISRCTN82927713; EudraCT2007-001716-23)-the researchers performed a secondary laboratory analysis.
The subject headings attached to it are Anemia, Iron-Deficiency, C-Reactive Protein, Cholecalciferol, Dietary Supplements, Ferritins, Hepcidins and Inflammation.
The authors tagged it with the keywords Vitamin D and pregnancy.
What This Means in Plain Language
The paper is a randomized, double-blind and placebo-controlled study of Vitamin D, K2, Magnesium and Zinc.
The publication is from 2019 (Nutrients), a journal based in Switzerland.
More context: the Vitamin D, K2, Magnesium and Zinc compound page, all human trials.
Our Notes on the Compound
Vitamin D, K2, Magnesium and Zinc: Magnesium is described as required for AMPK to function.
Related Pages
Source: PubMed record. This explanation is written by PeptideWhiz from the public record. For research and education only. Not medical advice; no dosing information is given.