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Vitamin B12-fortified toothpaste improves vitamin status in elderly people: a randomized, double-blind, placebo-controlled study
Plain-language guide to PMID 30680547 (2019): double-blind randomized controlled trial study of Cyanocobalamin (Vitamin B12) in 103 subjects.
Key Facts
- PMID
- 30680547
- Journal
- Aging clinical and experimental research
- Year
- 2019
- Study type
- Randomized Controlled Trial
- Authors
- Zant A et al. (5 authors)
- DOI
- 10.1007/s40520-019-01125-6
What This Study Did, in Plain Language
What Was Tested
Researchers studied Cyanocobalamin (Vitamin B12) in this randomized controlled trial publication.
Elderly people are at risk for vitamin B12 deficiency.
Who Took Part
According to the abstract, 103 subjects were involved.
The age groups tagged for this paper are middle-aged adults and older adults, both men and women.
The researchers conducted a randomized double-blind placebo-controlled intervention in 103 elderly subjects.
How the Study Was Run
In design terms this was a randomized, double-blind and placebo-controlled study.
Random assignment meant chance, not the researchers, decided who got Cyanocobalamin (Vitamin B12) and who got the comparison, which limits bias.
As a double-blind Cyanocobalamin (Vitamin B12) study, the assignments were hidden from both participants and investigators until the end.
The comparison arm used a placebo, so changes seen with Cyanocobalamin (Vitamin B12) could be set against what happens without it.
A time span of 3 months appears in the methods.
Serum concentrations of vitamin B12, holotranscobalamin (holoTC), methylmalonic acid (MMA), and plasma total homocysteine (tHcy) were measured at baseline and after 3 months.
What Was Measured
PubMed files the paper under topics including Biomarkers, Toothpastes, Vitamin B 12, Vitamin B 12 Deficiency and Vitamin B Complex.
Author keywords: Elderly, Holotranscobalamin, Supplementation and Vitamin B12 deficiency.
What This Means in Plain Language
The paper is a randomized, double-blind and placebo-controlled study of Cyanocobalamin (Vitamin B12) in 103 subjects over 3 months.
The abstract goes on to report its results in about 8 sentences; this page does not restate them, so read the paper for the findings and their limits.
The publication is from 2019 (Aging clinical and experimental research), a journal based in Germany.
More context: the Cyanocobalamin (Vitamin B12) compound page, all human trials.
Our Notes on the Compound
Cyanocobalamin (Vitamin B12): A synthetic form of vitamin B12 (cobalamin), an essential nutrient for DNA synthesis, red blood cell formation and neurological function.
Related Pages
Source: PubMed record. This explanation is written by PeptideWhiz from the public record. For research and education only. Not medical advice; no dosing information is given.