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Racial/Ethnic Differences in 25-Hydroxy Vitamin D and Parathyroid Hormone Levels and Cardiovascular Disease Risk Among Postmenopausal Women

Plain-language guide to PMID 30764690 (2019): observational study study of Parathyroid Hormone (PTH 1-84) in 79,705 women.

Key Facts

PMID
30764690
Journal
Journal of the American Heart Association
Year
2019
Study type
Observational Study
Authors
Zhang X et al. (11 authors)
DOI
10.1161/JAHA.118.011021

What This Study Did, in Plain Language

What Was Tested

This observational study paper looks at Parathyroid Hormone (PTH 1-84).

Methods and Results the researchers conducted a case-cohort study among 79 705 postmenopausal women, aged 50 to 79 years, who were free of CVD at baseline in the WHI-OS (Women's Health Initiative Observational Study).

A subcohort of 1300 black and 1500 white participants were randomly chosen as controls; a total of 550 black and 1500 white women who developed incident CVD during a mean follow-up of 11 years were chosen as cases.

Who Took Part

The abstract describes 79,705 women taking part.

By PubMed's age tags, the people studied were middle-aged adults and older adults, women only.

What Was Measured

The researchers directly measured total 25( OH )D, vitamin D-binding protein, albumin, parathyroid hormone, and calculated free and bioavailable 25( OH )D.

PubMed files the paper under topics including Biomarkers, Cardiovascular Diseases, Case-Control Studies, Ethnicity, Forecasting, Incidence and Parathyroid Hormone.

The authors tagged it with the keywords 25(OH)D, parathyroid hormone/calcitonin, vitamin D and women.

What This Means in Plain Language

This is an observational study of Parathyroid Hormone (PTH 1-84) in 79,705 women.

The publication is from 2019 (Journal of the American Heart Association), a journal based in England.

More context: the Parathyroid Hormone (PTH 1-84) compound page, all human trials.

Our Notes on the Compound

Parathyroid Hormone (PTH 1-84): The 84-amino-acid hormone that raises blood calcium; full-length PTH (Natpara) has been used in hypoparathyroidism. Teriparatide is its 1-34 fragment.

Related Pages

Source: PubMed record. This explanation is written by PeptideWhiz from the public record. For research and education only. Not medical advice; no dosing information is given.