Effect of Vitamin D supplementation on synovial tissue volume and subchondral bone marrow lesion volume in symptomatic knee osteoarthritis.

What Was Tested

This randomized controlled trial looks at Vitamin D, K2, Magnesium and Zinc.

Their aim was, using contrast-enhanced (CE) magnetic resonance imaging (MRI), to examine the effect of vitamin D therapy on synovial tissue volume (STV) and also subchondral bone marrow lesion (BML) volume in men and women with symptomatic knee OA.

Why It Was Studied

VIDEO was registered with EudraCT: ref. 2004-000169-37.

The protocol for the trial can be accessed at https://www.ctu.mrc.ac.uk/studies/all-studies/v/video/.

Who Took Part

By PubMed's age tags, the people studied were middle-aged adults and older adults, both men and women.

Subjects with serial images were assessed (N = 50) for STV and subchondral BML volume.

How the Study Was Run

The researchers set it up as a randomized, double-blind and placebo-controlled study.

Because people in this Vitamin D, K2, Magnesium and Zinc study were split into groups at random, differences between the groups are less likely to reflect who happened to join each one.

As a double-blind Vitamin D, K2, Magnesium and Zinc study, the assignments were hidden from both participants and investigators until the end.

The comparison arm used a placebo, so changes seen with Vitamin D, K2, Magnesium and Zinc could be set against what happens without it.

A subsample had serial CE MRI scans acquired during the trial.

The difference in the mean change from baseline in these structural outcomes between intervention and placebo groups was assessed using random-effects modelling.

What Was Measured

The subject headings attached to it are Bone Marrow, Cholecalciferol, England, Knee Joint, Magnetic Resonance Imaging, Osteoarthritis, Knee and Synovial Membrane.

The authors tagged it with the keywords Bone marrow lesions (BMLs), Synovitis and Vitamin D.

What This Means in Plain Language

The paper is a randomized, double-blind and placebo-controlled study of Vitamin D, K2, Magnesium and Zinc.

The abstract goes on to report its results in about 3 sentences; this page does not restate them, so read the paper for the findings and their limits.

The publication is from 2019 (BMC musculoskeletal disorders), a journal based in England.

More context: the Vitamin D, K2, Magnesium and Zinc compound page, all human trials.