Vitamin D-supplemented yogurt drink reduces Candida infections in a paediatric intensive care unit: a randomised, placebo-controlled clinical trial.

What Was Tested

This randomized controlled trial looks at Vitamin D, K2, Magnesium and Zinc.

Who Took Part

The age groups tagged for this paper are infants and young children, both men and women.

Four hundred sixteen eligible children aged between 12 months to 5 years old admitted to the PICU, who were on broad-spectrum antibiotic therapy, participated in the study.

Primary outcome was defined as the incidences of Candida colonisation (Candida isolated from rectal swab) 14 days after enrollment.

How the Study Was Run

The design is described as randomized and placebo-controlled.

Because people in this Vitamin D, K2, Magnesium and Zinc study were split into groups at random, differences between the groups are less likely to reflect who happened to join each one.

The comparison arm used a placebo, so changes seen with Vitamin D, K2, Magnesium and Zinc could be set against what happens without it.

Secondary outcome measures were Candida growth in blood (candidaemia) and urine (candiduria).

What Was Measured

Topics PubMed links to this paper include Candida, Candidiasis, Critical Illness, Dietary Supplements, Intensive Care Units, Pediatric, Length of Stay and Prevalence.

The authors tagged it with the keywords Candida infection, candidaemia, candiduria, paediatric intensive care unit and vitamin D.

What This Means in Plain Language

The paper is a randomized and placebo-controlled study of Vitamin D, K2, Magnesium and Zinc.

The abstract goes on to report its results in about 3 sentences; this page does not restate them, so read the paper for the findings and their limits.

The publication is from 2019 (Journal of human nutrition and dietetics : the official journal of the British Dietetic Association), a journal based in England.

More context: the Vitamin D, K2, Magnesium and Zinc compound page, all human trials.