A randomized double-blinded placebo controlled trial of ergocalciferol 40,000 versus 100, per week for vitamin D inadequacy in institutionalized postmenopausal women.

Plain-language guide to PMID 30784012 (2020): double-blind randomized controlled trial of Vitamin D, K2, Magnesium and Zinc in 94 subjects.

Key Facts

PMID: 30784012
Journal: Aging clinical and experimental research
Year: 2020
Study type: Randomized Controlled Trial
Authors: Mueangpaisarn P et al. (2 authors)
DOI: 10.1007/s40520-019-01151-4

What This Study Did, in Plain Language

What Was Tested

This randomized controlled trial looks at Vitamin D, K2, Magnesium and Zinc.

Vitamin D inadequacy is common in institutionalized post-menopausal women who are at the highest risk for osteoporotic fracture.

Who Took Part

The study group was 94 subjects.

By PubMed's age tags, the people studied were older adults and people over 80, women only.

A randomized double-blinded placebo-controlled trial was conducted in 94 institutionalized subjects with baseline 25(OH)D levels < 30 ng/mL.

How the Study Was Run

In design terms this was a randomized, double-blind and placebo-controlled study.

Random assignment meant chance, not the researchers, decided who got Vitamin D, K2, Magnesium and Zinc and who got the comparison, which limits bias.

Neither the subjects nor the staff measuring them knew who was on Vitamin D, K2, Magnesium and Zinc, so expectations could not easily colour the readings.

The comparison arm used a placebo, so changes seen with Vitamin D, K2, Magnesium and Zinc could be set against what happens without it.

Serum 25(OH)D levels, calcium, phosphate, handgrip strength, time up and go (TUG) test and quality of life by EQ-5D-5L were measured at baseline and 12 weeks after randomization.

What Was Measured

The subject headings attached to it are Ergocalciferols, Hand Strength, Postmenopause, Quality of Life, Vitamin D Deficiency and Vitamins.

The authors tagged it with the keywords Institutionalized and Postmenopausal women.

What This Means in Plain Language

The paper is a randomized, double-blind and placebo-controlled study of Vitamin D, K2, Magnesium and Zinc in 94 subjects.

Results are reported in around 7 sentences of the abstract; we leave them to the paper itself rather than summarise them.

The publication is from 2020 (Aging clinical and experimental research), a journal based in Germany.

More context: the Vitamin D, K2, Magnesium and Zinc compound page, all human trials.

Our Notes on the Compound

Vitamin D, K2, Magnesium and Zinc: Magnesium is described as required for AMPK to function.

Vitamin D, K2, Magnesium and Zinc in the library

Source: PubMed record. This explanation is written by PeptideWhiz from the public record. For research and education only. Not medical advice; no dosing information is given.