Positive effect of low dose vitamin D supplementation on growth of fetal bones: A randomized prospective study.

What Was Tested

This randomized controlled trial looks at Vitamin D, K2, Magnesium and Zinc.

The effect of vitamin D supplementation on growth of fetal bones during pregnancy is unclear.

In this prospective randomized trial, 140 patients were divided into two equally matched groups according to age, 25(OH)D level, exercise, and dietary intake.

Who Took Part

The study group was 140 patients.

The age groups tagged for this paper are adults, women only.

How the Study Was Run

The researchers set it up as a randomized and placebo-controlled study.

Random assignment meant chance, not the researchers, decided who got Vitamin D, K2, Magnesium and Zinc and who got the comparison, which limits bias.

Some patients received a placebo instead of Vitamin D, K2, Magnesium and Zinc, giving a reference point.

Then crown-rump length (CRL) and femur length (FL) during the first trimester and humerus and femur lengths as well as their proximal metaphyseal diameter (PMD), midshaft diameter (MSD) and distal metaphyseal diameter (DMD) in the second and third trimester were measured using ultrasonography technique.

What Was Measured

In this prospective randomized trial, 140 patients were divided into two equally matched groups according to age, 25(OH)D level, exercise, and dietary intake.

The subject headings attached to it are Bone Development, Calcifediol, Dietary Supplements, Femur, Fetus, Humerus and Ultrasonography, Prenatal.

The authors tagged it with the keywords Crown-rump length, Long bone and Vitamin D supplement.

What This Means in Plain Language

The paper is a randomized and placebo-controlled study of Vitamin D, K2, Magnesium and Zinc in 140 patients.

The publication is from 2019 (Bone), a journal based in United States.

More context: the Vitamin D, K2, Magnesium and Zinc compound page, all human trials.