← Human Trials & Peer-Reviewed Studies
l-Carnitine plus metformin in clomiphene-resistant obese PCOS women, reproductive and metabolic effects: a randomized clinical trial.
Plain-language guide to PMID 30806102 (2019): double-blind randomized controlled trial of L-Carnitine, pcos.
Key Facts
- PMID
- 30806102
- Journal
- Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology
- Year
- 2019
- Study type
- Randomized Controlled Trial
- Authors
- El Sharkwy I et al. (2 authors)
- DOI
- 10.1080/09513590.2019.1576622
What This Study Did, in Plain Language
What Was Tested
Researchers studied L-Carnitine in the context of pcos in this randomized controlled trial publication.
To evaluate the reproductive and metabolic effects of L-carnitine plus metformin in clomiphene citrate (CC) resistant obese polycystic ovary syndrome (PCOS) women.
Why It Was Studied
The primary outcome was clinical pregnancy rate.
The secondary outcomes were hormonal and metabolic profile changes in addition to ovulation and first trimester (13 weeks) miscarriage rates.
Who Took Part
By PubMed's age tags, the people studied were young adults and adults, women only.
A double-blinded randomized controlled clinical trial, clomiphene-citrate resistant obese women were allocated randomly to receive CC plus metformin and L-carnitine (n = 138) or CC plus metformin and placebo (n = 136).
How the Study Was Run
The design is described as randomized, double-blind and placebo-controlled.
The participants were allocated by chance, so the L-Carnitine group and the comparison group should start out alike.
Blinding on both sides kept the participants and researchers unaware of who received L-Carnitine.
The comparison arm used a placebo, so changes seen with L-Carnitine could be set against what happens without it.
What Was Measured
The primary outcome was clinical pregnancy rate.
The secondary outcomes were hormonal and metabolic profile changes in addition to ovulation and first trimester (13 weeks) miscarriage rates.
PubMed files the paper under topics including Blood Glucose, Carnitine, Clomiphene, Drug Resistance, Fertility Agents, Female, Hormones and Infertility, Female.
Author keywords: -Carnitine, metabolic effect, metformin, obese, polycystic ovary syndrome and reproductive effect.
What This Means in Plain Language
The paper is a randomized, double-blind and placebo-controlled study of L-Carnitine in people with pcos.
The publication is from 2019 (Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology), a journal based in England.
More context: the L-Carnitine compound page, PCOS research.
Our Notes on the Compound
L-Carnitine: An amino acid derivative that carries fatty acids into mitochondria for energy production.
Related Pages
Source: PubMed record. This explanation is written by PeptideWhiz from the public record. For research and education only. Not medical advice; no dosing information is given.