Vitamin D3 supplementation for 8 weeks leads to improved haematological status following the consumption of an iron-fortified breakfast cereal: a double-blind randomised controlled trial in iron-deficient women.

Plain-language guide to PMID 30819262 (2019): double-blind randomized controlled trial of Vitamin D, K2, Magnesium and Zinc and Parathyroid Hormone (PTH 1-84).

Key Facts

PMID: 30819262
Journal: The British journal of nutrition
Year: 2019
Study type: Randomized Controlled Trial
Authors: Ahmad Fuzi SF et al. (2 authors)
DOI: 10.1017/S0007114519000412

What This Study Did, in Plain Language

What Was Tested

The paper reports a study of Vitamin D, K2, Magnesium and Zinc and Parathyroid Hormone (PTH 1-84), published as a randomized controlled trial.

Blood samples were collected at baseline, interim (4 weeks) and post-intervention (8 weeks) for measurement of Fe and vitamin D status biomarkers.

The effect of intervention was analysed using mixed-model repeated-measures ANOVA.

Who Took Part

The age groups tagged for this paper are young adults and adults, women only.

How the Study Was Run

The researchers set it up as a randomized, double-blind and placebo-controlled study.

Because people in this Vitamin D, K2, Magnesium and Zinc study were split into groups at random, differences between the groups are less likely to reflect who happened to join each one.

As a double-blind Vitamin D, K2, Magnesium and Zinc study, the assignments were hidden from both participants and investigators until the end.

The comparison arm used a placebo, so changes seen with Vitamin D, K2, Magnesium and Zinc could be set against what happens without it.

What Was Measured

Blood samples were collected at baseline, interim (4 weeks) and post-intervention (8 weeks) for measurement of Fe and vitamin D status biomarkers.

The effect of intervention was analysed using mixed-model repeated-measures ANOVA.

PubMed files the paper under topics including Anemia, Iron-Deficiency, Breakfast, Cholecalciferol, Dietary Supplements, Edible Grain, Food, Fortified and Iron.

The authors tagged it with the keywords 25(OH)D 25-hydroxyvitamin D, HAMP antimicrobial peptide, MCH mean corpuscular Hb, PTH parathyroid hormone, UHT ultra-high temperature and VDBP vitamin D binding protein.

What This Means in Plain Language

The paper is a randomized, double-blind and placebo-controlled study of Vitamin D, K2, Magnesium and Zinc and Parathyroid Hormone (PTH 1-84).

The publication is from 2019 (The British journal of nutrition), a journal based in England.

More context: the Vitamin D, K2, Magnesium and Zinc compound page and the Parathyroid Hormone (PTH 1-84) compound page, all human trials.

Our Notes on the Compounds

Vitamin D, K2, Magnesium and Zinc: Magnesium is described as required for AMPK to function.

Parathyroid Hormone (PTH 1-84): The 84-amino-acid hormone that raises blood calcium; full-length PTH (Natpara) has been used in hypoparathyroidism. Teriparatide is its 1-34 fragment.

Source: PubMed record. This explanation is written by PeptideWhiz from the public record. For research and education only. Not medical advice; no dosing information is given.