Effect of Magnesium Sulfate Combined with Phentolamine and Nifedipine for Gestational Hypertension and Serum Levels of LIF and Apelin

What Was Tested

Researchers studied Apelin in this randomized controlled trial publication.

To investigate the effect of magnesium sulfate combined with phentolamine and nifedipine for the treatment of gestational hypertension and on the levels of serum LIF and Apelin.

Why It Was Studied

Obstetrics and Gynecology Clinics, The Affiliated Hospital North China University of Science and Technology, China, from September 2016 to February 2018.

Who Took Part

According to the abstract, 80 patients were involved.

The age groups tagged for this paper are adults, women only.

One hundred and sixty patients with gestational hypertension were randomly divided into a control group and an observation group, 80 patients in each group.

Control group was given magnesium sulfate alone, while observation group was added with phentolamine and nifedipine on the basis of the treatment in control group.

How the Study Was Run

In design terms this was a randomized study.

Because people in this Apelin study were split into groups at random, differences between the groups are less likely to reflect who happened to join each one.

Curative effects, pregnancy outcomes, and levels of serum LIF and Apelin were compared.

What Was Measured

PubMed files the paper under topics including Apelin, Biomarkers, China, Gestational Age, Hypertension, Pregnancy-Induced, Leukemia Inhibitory Factor and Magnesium Sulfate.

What This Means in Plain Language

The paper is a randomized study of Apelin in 80 patients.

Results are reported in around 4 sentences of the abstract; we leave them to the paper itself rather than summarise them.

The publication is from 2019 (Journal of the College of Physicians and Surgeons--Pakistan : JCPSP), a journal based in Pakistan.

More context: the Apelin compound page, all human trials.