Effects of a polysaccharide-based multi-ingredient supplement on salivary immunity in non-elite marathon runners.

What Was Tested

The paper reports a study of Copper (Supplement), published as a randomized controlled trial.

The researchers aimed to determine the impact of a standardized polysaccharide-based multi-ingredient supplement, Advanced Ambrotose© complex powder (AA) on salivary secretory Immunoglobulin A (sIgA) and pro- and anti-inflammatory protein levels before and after a marathon in non-elite runners.

Why It Was Studied

Extreme exercise may alter the innate immune system.

Glycans are involved in several biological processes including immune system regulation.

Who Took Part

By PubMed's age tags, the people studied were adults and middle-aged adults, men only.

How the Study Was Run

The researchers set it up as a randomized study.

Random assignment meant chance, not the researchers, decided who got Copper (Supplement) and who got the comparison, which limits bias.

Forty-one male marathon runners who completed the 42.195 km of the 2016 Barcelona marathon were randomly assigned to two study groups.

Saliva and blood samples were collected the day before the marathon and two days after the end of the race.

Salivary IgA, pro-inflammatory chemokines (Gro-alpha, Gro-beta, MCP-1) and anti-inflammatory proteins (Angiogenin, ACRP, Siglec 5) were determined using commercially ELISA kits in saliva supernatant.

Biochemical parameters, including C-reactive protein, cardiac biomarkers, and blood hemogram were also evaluated.

What Was Measured

The subject headings attached to it are Athletes, Biomarkers, C-Reactive Protein, Dietary Carbohydrates, Dietary Supplements, Immunity, Innate and Immunoglobulin A, Secretory.

Author keywords: Dietary plant-derived polydisperse polysaccharide supplementation, Glycans, Inflammatory chemokines, Marathon, Salivary sIgA and Strenuous exercise.

What This Means in Plain Language

The paper is a randomized study of Copper (Supplement).

The abstract goes on to report its results in about 4 sentences; this page does not restate them, so read the paper for the findings and their limits.

The publication is from 2019 (Journal of the International Society of Sports Nutrition), a journal based in United States.

More context: the Copper (Supplement) compound page, all human trials.