Comparison of analog insulin mix 50:50 with human insulin mix 30:70 in persons with type 2 diabetes during Ramadan

What Was Tested

Researchers studied Insulin Lispro and NPH Insulin (isophane) in this randomized controlled trial publication.

Who Took Part

The abstract describes 20 subjects taking part.

The age groups tagged for this paper are adults, middle-aged adults and older adults, both men and women.

Pre-Ramadan and during Ramadan fasting and postprandial (3 hours) and pre-Suhur blood glucose (BG) are tested in 20 subjects and 20 controls by the patients using home glucose meters.

Severe hypoglycaemia occurred if the patient needed assistance for recovery.

How the Study Was Run

The design is described as randomized.

Because people in this Insulin Lispro study were split into groups at random, differences between the groups are less likely to reflect who happened to join each one.

Pre- and post-Ramadan HbA1 c and body weight are measured.

The number of days fasted and baseline characteristics are age, gender, and duration of diabetes are also noted.

Differences between groups in parameters were assessed using ANCOVA to adjust for pre-Ramadan values of age, gender, and duration of diabetes.

What Was Measured

Topics PubMed links to this paper include Biomarkers, Biphasic Insulins, Blood Glucose, Diabetes Mellitus, Type 2, Fasting, Glycated Hemoglobin and Holidays.

What This Means in Plain Language

The paper is a randomized study of Insulin Lispro and NPH Insulin (isophane) in 20 subjects.

With fewer than 40 people, it is a small study, so it is better read as an early signal for further research than as a settled answer.

Its findings take up roughly 7 sentences of the abstract and are left out here on purpose; the source paper is the place to read them.

The publication is from 2019 (International journal of clinical practice), a journal based in United States.

More context: the Insulin Lispro compound page and the NPH Insulin (isophane) compound page, all human trials.