The effects of magnesium-zinc-calcium-vitamin D co-supplementation on biomarkers of inflammation, oxidative stress and pregnancy outcomes in gestational diabetes.

Plain-language guide to PMID 30922259 (2019): double-blind randomized controlled trial of Vitamin D, K2, Magnesium and Zinc in 60 women.

Key Facts

PMID: 30922259
Journal: BMC pregnancy and childbirth
Year: 2019
Study type: Randomized Controlled Trial
Authors: Jamilian M et al. (7 authors)
DOI: 10.1186/s12884-019-2258-y

What This Study Did, in Plain Language

What Was Tested

This randomized controlled trial looks at Vitamin D, K2, Magnesium and Zinc.

This study was aimed to determine the effects of magnesium-zinc-calcium-vitamin D co-supplementation on parameters of inflammation and oxidative stress, and pregnancy outcomes among women with GDM.

Why It Was Studied

Diabetes is the most common medical condition in pregnant women and its complications affect both mother and fetus.

Who Took Part

According to the abstract, 60 women were involved.

The age groups tagged for this paper are young adults and adults, women only.

This randomized, double-blinded, placebo-controlled trial was conducted on 60 women with GDM not taking oral hypoglycemic agents.

How the Study Was Run

The design is described as randomized, double-blind and placebo-controlled.

Because people in this Vitamin D, K2, Magnesium and Zinc study were split into groups at random, differences between the groups are less likely to reflect who happened to join each one.

Neither the women nor the staff measuring them knew who was on Vitamin D, K2, Magnesium and Zinc, so expectations could not easily colour the readings.

The comparison arm used a placebo, so changes seen with Vitamin D, K2, Magnesium and Zinc could be set against what happens without it.

What Was Measured

PubMed files the paper under topics including Antioxidants, Biomarkers, Birth Weight, C-Reactive Protein, Calcium, Diabetes, Gestational and Dietary Supplements.

Author keywords: Gestational diabetes, Inflammation, Multinutrients, Pregnancy and Supplementation.

What This Means in Plain Language

The paper is a randomized, double-blind and placebo-controlled study of Vitamin D, K2, Magnesium and Zinc in 60 women.

Its findings take up roughly 4 sentences of the abstract and are left out here on purpose; the source paper is the place to read them.

The publication is from 2019 (BMC pregnancy and childbirth), a journal based in England.

More context: the Vitamin D, K2, Magnesium and Zinc compound page, all human trials.

Our Notes on the Compound

Vitamin D, K2, Magnesium and Zinc: Magnesium is described as required for AMPK to function.

Vitamin D, K2, Magnesium and Zinc in the library

Source: PubMed record. This explanation is written by PeptideWhiz from the public record. For research and education only. Not medical advice; no dosing information is given.