Response to ovulation trigger is correlated to late follicular phase progesterone levels: A hypothesis explaining reduced reproductive outcomes caused by increased late follicular progesterone rise

What Was Tested

This randomized controlled trial paper looks at hCG (human chorionic gonadotropin) and Buserelin.

Is there an association between progesterone (P4) levels on the day of hCG or GnRH trigger and on the day of oocyte retrieval in IVF/ICSI cycles?

FSH induces LH receptor (LHR) expression on granulosa cells, and LHR produces progesterone when exposed to LH-like activity.

Who Took Part

The abstract describes 384 participants taking part.

By PubMed's age tags, the people studied were young adults and adults, women only.

How the Study Was Run

In design terms this was a randomized study.

The participants were allocated by chance, so the hCG (human chorionic gonadotropin) group and the comparison group should start out alike.

This study is based on data from a previously published RCT conducted from 2009 to 2011.

P4 was measured on the day of ovulation induction and on the day of oocyte retrieval.

FSH consumption and number of retrieved follicles were recorded.

What Was Measured

Is there an association between progesterone (P4) levels on the day of hCG or GnRH trigger and on the day of oocyte retrieval in IVF/ICSI cycles?

Topics PubMed links to this paper include Buserelin, Chorionic Gonadotropin, Fertility Agents, Female, Fertilization in Vitro, Follicular Phase, Gonadotropin-Releasing Hormone and Granulosa Cells.

Author keywords: GnRHa trigger, IVF, early luteal phase, hCG trigger, ovulation induction and reproductive outcome.

What This Means in Plain Language

The paper is a randomized study of hCG (human chorionic gonadotropin) and Buserelin in 384 participants.

With several hundred people or more, it is a fairly large study for this kind of research.

Results are reported in around 6 sentences of the abstract; we leave them to the paper itself rather than summarise them.

The publication is from 2019 (Human reproduction (Oxford, England)), a journal based in England.

More context: the hCG (human chorionic gonadotropin) compound page and the Buserelin compound page.