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Effects of supplemental calcium and vitamin D on tight-junction proteins and mucin-12 expression in the normal rectal mucosa of colorectal adenoma patients.
Plain-language guide to PMID 30938860 (2019): randomized controlled trial of Vitamin D, K2, Magnesium and Zinc in 105 participants.
Key Facts
- PMID
- 30938860
- Journal
- Molecular carcinogenesis
- Year
- 2019
- Study type
- Randomized Controlled Trial
- Authors
- Mandle HB et al. (10 authors)
- DOI
- 10.1002/mc.23010
What This Study Did, in Plain Language
What Was Tested
This randomized controlled trial looks at Vitamin D, K2, Magnesium and Zinc.
The physical gut barrier, comprised of a thick mucus layer and the epithelium, plays an important role in defense against microbes and foreign antigens.
Calcium and vitamin D may be involved in maintaining the integrity of the intestinal mucosal barrier, the dysfunction of which may lead to endotoxemia and inflammation, and contribute to colorectal carcinogenesis.
Who Took Part
According to the abstract, 105 participants were involved.
By PubMed's age tags, the people studied were middle-aged adults and older adults, both men and women.
How the Study Was Run
In design terms this was a randomized study.
Because people in this Vitamin D, K2, Magnesium and Zinc study were split into groups at random, differences between the groups are less likely to reflect who happened to join each one.
What Was Measured
Calcium and vitamin D may be involved in maintaining the integrity of the intestinal mucosal barrier, the dysfunction of which may lead to endotoxemia and inflammation, and contribute to colorectal carcinogenesis.
The researchers assessed expression of the tight junction proteins claudin-1 (CLDN1), occludin (OCLD), and mucin-12 (MUC12) in the normal-appearing colorectal mucosa using standardized, automated immunohistochemistry and quantitative image analysis.
The subject headings attached to it are Adenomatous Polyposis Coli, Biomarkers, Tumor, Calcium, Dietary, Cholecalciferol, Claudin-1, Colorectal Neoplasms and Dietary Supplements.
The authors tagged it with the keywords mucin-12, occludin and vitamin D.
What This Means in Plain Language
The paper is a randomized study of Vitamin D, K2, Magnesium and Zinc in 105 participants.
The publication is from 2019 (Molecular carcinogenesis), a journal based in United States.
More context: the Vitamin D, K2, Magnesium and Zinc compound page, all human trials.
Our Notes on the Compound
Vitamin D, K2, Magnesium and Zinc: Magnesium is described as required for AMPK to function.
Related Pages
Source: PubMed record. This explanation is written by PeptideWhiz from the public record. For research and education only. Not medical advice; no dosing information is given.