Efficacy and safety of moisturizer containing 5% panthenol, madecassoside, and copper-zinc-manganese versus 0.02% triamcinolone acetonide cream in decreasing adverse reaction and downtime after ablative fractional carbon dioxide laser resurfacing: A split-face, double-blinded, randomized, controlled trial.

Plain-language guide to PMID 30945430 (2019): double-blind randomized controlled trial of Vitamin D, K2, Magnesium and Zinc and Copper (Supplement) in 20 subjects.

Key Facts

PMID: 30945430
Journal: Journal of cosmetic dermatology
Year: 2019
Study type: Randomized Controlled Trial
Authors: Lueangarun S et al. (3 authors)
DOI: 10.1111/jocd.12951

What This Study Did, in Plain Language

What Was Tested

Researchers studied Vitamin D, K2, Magnesium and Zinc and Copper (Supplement) in this randomized controlled trial publication.

Who Took Part

According to the abstract, 20 subjects were involved.

By PubMed's age tags, the people studied were adults and middle-aged adults, both men and women.

Clinical, expert panel assessment of photography, downtime, side effects, and biometric evaluation for erythema and melanin were performed on baseline, immediately after treatment, day 3, 5, 7, 14, 30 and, 60 postoperatively.

How the Study Was Run

In design terms this was a randomized and double-blind study.

The subjects were allocated by chance, so the Vitamin D, K2, Magnesium and Zinc group and the comparison group should start out alike.

As a double-blind Vitamin D, K2, Magnesium and Zinc study, the assignments were hidden from both participants and investigators until the end.

What Was Measured

The subject headings attached to it are Acne Vulgaris, Anti-Inflammatory Agents, Cicatrix, Erythema, Laser Therapy, Lasers, Gas and Photography.

Author keywords: anti-inflammation, copper-zinc-manganese, fractional ablative laser, madecassoside, moisturizer and panthenol.

What This Means in Plain Language

The paper is a randomized and double-blind study of Vitamin D, K2, Magnesium and Zinc and Copper (Supplement) in 20 subjects.

With fewer than 40 people, it is a small study, so it is better read as an early signal for further research than as a settled answer.

Its findings take up roughly 3 sentences of the abstract and are left out here on purpose; the source paper is the place to read them.

The publication is from 2019 (Journal of cosmetic dermatology), a journal based in England.

More context: the Vitamin D, K2, Magnesium and Zinc compound page and the Copper (Supplement) compound page, all human trials.

Our Notes on the Compounds

Vitamin D, K2, Magnesium and Zinc: Magnesium is described as required for AMPK to function.

Copper (Supplement): The active site of cytochrome c oxidase is described as containing copper ions that are essential for electron transfer.

Source: PubMed record. This explanation is written by PeptideWhiz from the public record. For research and education only. Not medical advice; no dosing information is given.