Monthly high-dose vitamin D supplementation does not increase kidney stone risk or serum calcium: results from a randomized controlled trial.

What Was Tested

The paper reports a study of Vitamin D, K2, Magnesium and Zinc, published as a randomized controlled trial.

The researchers investigated the incidence of kidney stone and hypercalcemia events in a large, population-based RCT of vitamin D supplementation.

Why It Was Studied

However, there are limited RCT data on the safety of calcium-related adverse effects.

Who Took Part

The abstract describes 5110 participants taking part.

PubMed indexes the participants as middle-aged adults, older adults and people over 80, both men and women.

Participants provided information about recent kidney stone events in regular questionnaires sent to them with study capsules.

How the Study Was Run

The researchers set it up as a randomized, double-blind and placebo-controlled study.

Because people in this Vitamin D, K2, Magnesium and Zinc study were split into groups at random, differences between the groups are less likely to reflect who happened to join each one.

As a double-blind Vitamin D, K2, Magnesium and Zinc study, the assignments were hidden from both participants and investigators until the end.

Some participants received a placebo instead of Vitamin D, K2, Magnesium and Zinc, giving a reference point.

Hospitalization data for kidney stones were collected from health authorities.

HRs of time to the first kidney stone event were calculated by Cox regression.

What Was Measured

The subject headings attached to it are Calcium, Dietary Supplements, Hypercalcemia, Kidney Calculi and Vitamin D.

Author keywords: kidney stone, randomized controlled trial and vitamin D supplementation.

What This Means in Plain Language

The paper is a randomized, double-blind and placebo-controlled study of Vitamin D, K2, Magnesium and Zinc in 5110 participants.

With several hundred people or more, it is a fairly large study for this kind of research.

Its findings take up roughly 7 sentences of the abstract and are left out here on purpose; the source paper is the place to read them.

The publication is from 2019 (The American journal of clinical nutrition), a journal based in United States.

More context: the Vitamin D, K2, Magnesium and Zinc compound page, all human trials.