Establishing an electronic health record-supported approach for outreach to and recruitment of persons at high risk of type 2 diabetes in clinical trials: The vitamin D and type 2 diabetes (D2d) study experience.

What Was Tested

This randomized controlled trial looks at Vitamin D, K2, Magnesium and Zinc.

To establish recruitment approaches that leverage electronic health records in multicenter prediabetes/diabetes clinical trials and compare recruitment outcomes between electronic health record-supported and conventional recruitment methods.

Who Took Part

PubMed indexes the participants as middle-aged adults and older adults.

Observational analysis of recruitment approaches in the vitamin D and type 2 diabetes (D2d) study, a multicenter trial in participants with prediabetes.

Outcomes were adoption of electronic health record-supported recruitment approaches by sites, number of participants screened, recruitment performance (proportion screened who were randomized), and characteristics of participants from electronic health record-supported versus non-electronic health record methods.

How the Study Was Run

In design terms this was a randomized, double-blind and multicenter study.

Random assignment meant chance, not the researchers, decided who got Vitamin D, K2, Magnesium and Zinc and who got the comparison, which limits bias.

As a double-blind Vitamin D, K2, Magnesium and Zinc study, the assignments were hidden from both participants and investigators until the end.

More than one site took part, so the participants came from several places.

What Was Measured

The subject headings attached to it are Blood Glucose, Cholecalciferol, Comorbidity, Diabetes Mellitus, Type 2, Dietary Supplements, Electronic Health Records and Glycated Hemoglobin.

Author keywords: Prediabetes, recruitment and trial.

What This Means in Plain Language

The paper is a randomized, double-blind and multicenter study of Vitamin D, K2, Magnesium and Zinc.

Results are reported in around 6 sentences of the abstract; we leave them to the paper itself rather than summarise them.

The publication is from 2019 (Clinical trials (London, England)), a journal based in England.

More context: the Vitamin D, K2, Magnesium and Zinc compound page, all human trials.