Acute Effects of Single Doses of Bonito Fish Peptides and Vitamin D on Whole Blood Gene Expression Levels: A Randomized Controlled Trial.

What Was Tested

Researchers studied Vitamin D, K2, Magnesium and Zinc in this randomized controlled trial publication.

Fish contains high quality proteins and essential nutrients including 25-hydroxyvitamin D (25(OH)D).

A randomized, crossover, placebo controlled trial was conducted in 22 adults.

Who Took Part

According to the abstract, 22 adults were involved.

By PubMed's age tags, the people studied were young adults, adults, middle-aged adults and older adults, both men and women.

How the Study Was Run

The design is described as randomized, placebo-controlled and crossover.

The adults were allocated by chance, so the Vitamin D, K2, Magnesium and Zinc group and the comparison group should start out alike.

A placebo (an inactive look-alike) gave the Vitamin D, K2, Magnesium and Zinc group a baseline to be compared against.

In the crossover set-up each of the adults took both Vitamin D, K2, Magnesium and Zinc and the comparison in turn, acting as their own control.

What Was Measured

A 180 min oral glucose tolerance test was performed.

The subject headings attached to it are Blood Glucose, C-Peptide, Cohort Studies, Fishes, Gene Expression Regulation, Glucose Tolerance Test and Insulin.

Author keywords: cardiometabolic risk, cholecalciferol and nutrigenomics.

What This Means in Plain Language

The paper is a randomized, placebo-controlled and crossover study of Vitamin D, K2, Magnesium and Zinc in 22 adults.

With fewer than 40 people, it is a small study, so it is better read as an early signal for further research than as a settled answer.

The publication is from 2019 (International journal of molecular sciences), a journal based in Switzerland.

More context: the Vitamin D, K2, Magnesium and Zinc compound page, all human trials.