Local In Vivo Measures of Muscle Lipid and Oxygen Consumption Change in Response to Combined Vitamin D Repletion and Aerobic Training in Older Adults.

Plain-language guide to PMID 31027191 (2019): double-blind randomized controlled trial of Vitamin D, K2, Magnesium and Zinc.

Key Facts

PMID: 31027191
Journal: Nutrients
Year: 2019
Study type: Randomized Controlled Trial
Authors: Thomas DT et al. (8 authors)
DOI: 10.3390/nu11040930

What This Study Did, in Plain Language

What Was Tested

This randomized controlled trial looks at Vitamin D, K2, Magnesium and Zinc.

This study compared the change in [IMCL]:[EMCL] following the combined treatment of vitamin D and aerobic training (DAT) compared with vitamin D (D), aerobic training (AT), and control (CTL).

Hybrid near-infrared diffuse correlation spectroscopy measured hemodynamics.

Who Took Part

By PubMed's age tags, the people studied were middle-aged adults and older adults, both men and women.

Male and female subjects aged 60-80 years with a BMI ranging from 18.5-34.9 and vitamin D status of ≤32 ng/mL (25(OH)D) were recruited to randomized, prospective clinical trial double-blinded for supplement with a 2 × 2 factorial design.

How the Study Was Run

The design is described as randomized, double-blind and placebo-controlled.

The participants were allocated by chance, so the Vitamin D, K2, Magnesium and Zinc group and the comparison group should start out alike.

Blinding on both sides kept the participants and researchers unaware of who received Vitamin D, K2, Magnesium and Zinc.

The comparison arm used a placebo, so changes seen with Vitamin D, K2, Magnesium and Zinc could be set against what happens without it.

Gastrocnemius IMCL and EMCL were measured with magnetic resonance spectroscopy (MRS) and MRI.

What Was Measured

Hybrid near-infrared diffuse correlation spectroscopy measured hemodynamics.

The subject headings attached to it are Dietary Supplements, Exercise, Lipid Metabolism, Muscle, Skeletal, Oxygen Consumption and Vitamin D.

The authors tagged it with the keywords IMCL, metabolic function, sarcopenia and skeletal muscle.

What This Means in Plain Language

The paper is a randomized, double-blind and placebo-controlled study of Vitamin D, K2, Magnesium and Zinc.

The publication is from 2019 (Nutrients), a journal based in Switzerland.

More context: the Vitamin D, K2, Magnesium and Zinc compound page, all human trials.

Our Notes on the Compound

Vitamin D, K2, Magnesium and Zinc: Magnesium is described as required for AMPK to function.

Vitamin D, K2, Magnesium and Zinc in the library

Source: PubMed record. This explanation is written by PeptideWhiz from the public record. For research and education only. Not medical advice; no dosing information is given.