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The effects of magnesium supplementation on gene expression related to inflammatory markers, vascular endothelial growth factor, and pregnancy outcomes in patients with gestational diabetes.
Plain-language guide to PMID 31099333 (2018): double-blind randomized controlled trial of Vitamin D, K2, Magnesium and Zinc in 36 women.
Key Facts
- PMID
- 31099333
- Journal
- Magnesium research
- Year
- 2018
- Study type
- Randomized Controlled Trial
- Authors
- Ahmadi S et al. (7 authors)
- DOI
- 10.1684/mrh.2019.0446
What This Study Did, in Plain Language
What Was Tested
Researchers studied Vitamin D, K2, Magnesium and Zinc in this randomized controlled trial publication.
The aim of this study was to evaluate the effects of magnesium supplementation on gene expression of inflammatory markers, vascular endothelial growth factor (VEGF), and pregnancy outcomes in women diagnosed with gestational diabetes mellitus (GDM).
Why It Was Studied
This randomized, double-blinded, placebo-controlled trial was conducted among 36 women, aged 18-40 years old, diagnosed with GDM.
Who Took Part
The study group was 36 women.
PubMed indexes the participants as teenagers, young adults and adults, women only.
Gene expression related to inflammatory markers and VEGF was assessed using peripheral blood mononuclear cells (PBMCs) of women with GDM, via RT-PCR method.
How the Study Was Run
In design terms this was a randomized, double-blind and placebo-controlled study.
The women were allocated by chance, so the Vitamin D, K2, Magnesium and Zinc group and the comparison group should start out alike.
Neither the women nor the staff measuring them knew who was on Vitamin D, K2, Magnesium and Zinc, so expectations could not easily colour the readings.
Some women received a placebo instead of Vitamin D, K2, Magnesium and Zinc, giving a reference point.
What Was Measured
PubMed files the paper under topics including Biomarkers, Diabetes, Gestational, Dietary Supplements, Gene Expression Profiling, Gene Expression Regulation, Inflammation and Magnesium.
The authors tagged it with the keywords gestational diabetes and pregnancy outcomes.
What This Means in Plain Language
The paper is a randomized, double-blind and placebo-controlled study of Vitamin D, K2, Magnesium and Zinc in 36 women.
With fewer than 40 people, it is a small study, so it is better read as an early signal for further research than as a settled answer.
The publication is from 2018 (Magnesium research), a journal based in England.
More context: the Vitamin D, K2, Magnesium and Zinc compound page, all human trials.
Our Notes on the Compound
Vitamin D, K2, Magnesium and Zinc: Magnesium is described as required for AMPK to function.
Related Pages
Source: PubMed record. This explanation is written by PeptideWhiz from the public record. For research and education only. Not medical advice; no dosing information is given.