Vaginal misoprostol before copper IUD insertion after previous insertion failure: a double-blind, placebo-controlled, parallel-group, randomised clinical trial.

What Was Tested

The paper reports a study of Copper (Supplement), published as a randomized controlled trial.

Methods: A single-centre, parallel-group, double-blind, placebo-controlled, randomised clinical trial was conducted at Ain Shams University Maternity Hospital, Cairo, Egypt, between October 2015 and August 2016.

The study comprised 90 parous women undergoing TCu380A IUD insertion after a failed attempt.

Who Took Part

According to the abstract, 90 women were involved.

By PubMed's age tags, the people studied were young adults and adults, women only.

How the Study Was Run

The researchers set it up as a randomized, double-blind, placebo-controlled and parallel-group study.

Because people in this Copper (Supplement) study were split into groups at random, differences between the groups are less likely to reflect who happened to join each one.

As a double-blind Copper (Supplement) study, the assignments were hidden from both participants and investigators until the end.

A placebo (an inactive look-alike) gave the Copper (Supplement) group a baseline to be compared against.

The Copper (Supplement) group and the comparison group ran side by side rather than switching.

What Was Measured

The primary outcome was the success of IUD insertion.

Secondary outcomes were to establish the effect on insertion success of cervical dilation, cervical softening and previous mode of delivery.

Topics PubMed links to this paper include Administration, Intravaginal, Cervix Uteri, Cesarean Section, Dilatation, Intrauterine Devices, Copper, Misoprostol and Oxytocics.

The authors tagged it with the keywords Copper intrauterine device, insertion failure and intrauterine contraception.

What This Means in Plain Language

The paper is a randomized, double-blind and placebo-controlled study of Copper (Supplement) in 90 women.

The publication is from 2019 (The European journal of contraception & reproductive health care : the official journal of the European Society of Contraception), a journal based in England.

More context: the Copper (Supplement) compound page, all human trials.